Mitochondrial Intoxication

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Häftad, Engelska, 2026

2 039 kr

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Mitochondrial Intoxication, Second Edition offers a comprehensive and fully updated exploration of the impact of toxic molecules on mitochondrial physiology, and the diseases that result from their dysfunction. Divided into three sections, the book opens with a detailed overview of mitochondrial physiology, molecular markers of mitochondrial intoxication and challenges of mitochondrial profiling during pre-clinical studies. It then focuses on endogenous toxicants and their impact on mitochondria, including new chapters on lipids, glucose and microbiota-derived toxicants. Amyloid-? peptide and its impact on mitochondrial dysfunction is also a new addition to this book, as well as inflammation-induced mitochondrial intoxication. The final section explores exogenous toxicants, such as pollutants, food additives, illicit and pharmaceutical drugs, pesticides and heavy metals. The effects of micro- and nanoplastics on mitochondrial function are newly covered. Furthermore, the latest computational tools in mitochondrial toxicity research are investigated. Incorporating the latest advances in the field, “Mitochondrial Intoxication, Second Edition” offers cutting-edge insights on mitochondrial toxicity, and serves as an invaluable resource for researchers and advanced students in cell biology, molecular biology, toxicology, biochemistry, pharmacology, and related fields.

Covers molecular markers of mitochondrial intoxication
Includes case studies that illustrate the health impacts of toxicity upon mitochondria
Provides new insights on environmental contaminants like microbiota-derived molecules and micro- and nanoplastics and their impact on mitochondrial physiology
Investigates endogenous molecules such as cholesterol, glucose, and beta-amyloid peptides affecting mitochondrial health
Explores computational tools and their application to mitochondrial toxicity research

Produktinformation

Utgivningsdatum2026-09-01
Mått191 x 235 x undefined mm
Vikt450 g
FormatHäftad
SpråkEngelska
Antal sidor900
Upplaga2
FörlagElsevier Science
ISBN9780443450785

Tillhör följande kategorier

Farmakologi inom Medicin
Biologi inom Naturvetenskap och teknik

Marcos Roberto de Oliveira, PhD earned his bachelor’s degree in Biological Sciences at Federal University of Rio Grande do Sul (UFRGS) in 2005, followed by a master’s and a Ph.D. in Biochemistry from the same institution. He is currently a professor and coordinates research at UFRGS. His research focuses on the neuroprotection mediated by natural molecules and involves studies on mitochondrial physiology, redox biology, bioenergetics, and inflammation in both in vitro and in vivo experimental models.

Section 1: Introduction1. Mitochondrial physiology: An overview2. Molecular markers of mitochondrial intoxication3. Challenges in mitochondrial profiling during pre-clinical studiesSection 2: Endogenous toxicants4. Ammonia5. Amyloid-β peptide and mitochondrial dysfunction6. Lipids-induced mitochondrial intoxication7. Glucose-induced mitochondrial intoxication8. The effects of methylglyoxal on the mitochondria9. Inflammation-induced mitochondrial intoxication10. Microbiota-derived toxicants targeting mitochondriaSection 3: Exogenous toxicants11. Drug-induced mitochondrial impairment: Mechanisms and testing systems12. Clinical consequences of drug-induced mitochondrial dysfunction13. Mitochondrial dysfunction and underlying molecular mechanisms in acrylamide-induced toxicity14. The effects of air pollution toxicants on the mitochondria15. Mitochondrial toxicity of aflatoxin B116. The effects of the alcohol abuse against the mitochondria: functional consequences for liver, muscle, and the brain17. The effect of aluminium on mitochondrial dysfunctions18. Discovery of amiodarone mitochondrial toxicity in liver and beyond19. The mitochondrial disruption as a contributing factor for the neurotoxicity of amphetamines20. Mitochondrial intoxication by anthracyclines21. Antidepressants, mood-stabilizing drugs, and mitochondrial function: for better or for worse22. The effects of HIV and the antiretrovirals on the mitochondria23. Mechanisms of bisphenol A toxicity in mitochondria24. Chemotherapeutic drugs25. Effects of food additives on the mitochondria integrity and26. Mitochondria as a toxicological target for fungicides27. The effects of mercury on the mitochondria28. Mitochondrial intoxication induced by micro- and nanoplastics29. Organohalides30. The effects of organophosphate pesticides on the mitochondria31. Mitochondrial oxygen toxicity32. Polychlorinated biphenyls33. The effects of polycyclic aromatic hydrocarbons on mitochondria34. The effects of pyrethroids on the mitochondria35. The effects of sodium nitrate on the mitochondria36. Effects of Δ9-tetrahydrocannabinol on mitochondria37. Mitochondrial zinc toxicity

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