Mitochondria in Health and Disease

Carolyn D. Berdanier

• Preface. Introduction to Mitochondria. Bioenergetics of Mitochondria. Mitochondrial Genome and Mitochondrial Function. Mitochondrial Diseases in Growth and Development. Using Mitochondria in Population Surveys. Mitochondrial DNA Mutation, Oxidative Stress and Alterations of Gene Expression in Human Aging. Mitochondrial Mutations in Vision. Mitochondrial DNA in Cardiomyopathies. Mitochondria in Diabetes. Drugs, Nutrients and Hormones in Mitochondrial Function. Bacterial F1F0ATP Synthase as a Model for Complex V. Cybrids and the Manipulation of Mitochondrial Genotype. Animal Modeling: From Transgenics to Transmitochondrial Models. BHE/Cdb Rats as Tools to Study Mitochondrial Mutation.