Mitochondria and Cell Death

David M. Hockenbery, MD is Professor, Member & Head of the Gastroenterology & Hepatology Section of the Fred Hutchinson Cancer Research Center, Seattle Cancer Care Alliance. He is also a Mentor in the Seattle Children’s/UW/Hutchinson Center Pediatric Hematology-Oncology Fellowship Program. He received his M.D. from Washington University in St. Louis, completed his Residency in Medicine at Johns Hopkins and also completed two Fellowships, in Gastroenterology and Molecular Oncology, at Washington University. Dr. Hockenbery’s current research interests include the bcl-2 oncogene and its role in apoptosis, mitochondrial biology and bioenergetic metabolism, utilizing cell culture, transgenic mouse and protein biochemistry approaches for identification of cancer-selective metabolic pathways and discovery of small molecule inhibitors targeting these pathways.

• Preface.- 1.Lethal and non-lethal functions of the permeability transition pore.- 2.Mitochondrial Calcium and Ischemia-Reperfusion Injury inHeart.- 3.Mislocalization of mitochondrial intermembrane space proteins.- 4.Bcl-2 protein interplay on the outer mitochondrial membrane.- 5.Remodeling of Mitochondria in Apoptosis.- 6.Physiologic and Pathologic Functions of Mitochondrial ROS.- 7.Mitochondrial Mutagenesis in Cancer.- 8.Mitochondrial UPR in cancer.- 9.Mitochondrial signaling.- 10.Mitochondria and antiviral immunity.- 11.Mitochondrial permeabilization from lethality to vitality.- Index.