Faisal I. Khan is a Chemical Engineering Professor and Director of the Mary Kay O'Connor Process Safety Center and the Ocean Energy Safety Institute (OESI), Texas A&M University. He is the founder of the Centre for Risk Integrity and Safety Engineering (C-RISE), a Fellow of the Canadian Academy of Engineering, the Engineering Institute of Canada, and the Canadian Society of Chemical Engineering. His areas of research interest include offshore safety and risk engineering, inherent safety, risk management, and risk-based integrity assessment and management. Dr. Khan is actively involved with multinational oil and gas industries in addressing safety and asset integrity issues. He also served as the Safety and Risk Advisor to the Government of Newfoundland and Labrador, Canada. He continues to serve as a subject matter expert to many organizations, including Lloyd's Register EMEA, SBM Modco, Intecsea, Technip, and Qatar Gas. He served as a Visiting Professor of Offshore and Marine Engineering at the Australian Maritime College (AMC), University of Tasmania, Australia, where he led the development of the offshore safety and risk engineering group and initiated global engagements with numerous international institutions. Dr. Khan is the recipient of the President's Outstanding Research Award of 2012–13 at Memorial University, the President's Outstanding Research Supervision Award of 2013–14 at Memorial University, the CSChE National Award on Process Safety Management of 2014, and the Society of Petroleum Engineers award for his contribution to Health, Safety, and Risk Engineering. He has authored over 500 research articles in peer-reviewed journals and conferences on safety, risk, and reliability engineering. He has authored five books on the subject area. He is the Editor of the Journal of Process Safety and Environmental Protection, Safety in Extreme Environment, and ASME Part A (Risk and Uncertainty Analysis). He regularly offers training programs/workshops on safety and risk engineering in various locations, including St. John's, Chennai, Dubai, Beijing, Aberdeen, Cape Town, Doha, and Kuala Lumpur. TEES Research Professor, Mary Kay O'Connor Process Safety Center, Texas A&M University, Texas, USA., Emeritus Professor, Chemical Risk Management of the Delft University of Technology, and associated member of the Dutch Council for Life Environment and Infrastructure in the Netherlands. Professor Pasman graduated in Chemical Technology at Delft University of Technology in 1961, and finished a Doctor’s thesis in 1964 while working for Shell. He joined the Dutch Organisation for Applied Research, TNO, in 1965, initiating and performing research in reactive materials, gas, dust and energetic material explosions, investigation of industrial accidents and risk analysis, while also managing organizational units. He has been a member of the Working Party on Loss Prevention and Safety Promotion in the Process Industries since 1972, and chairman from 1986-2004. In this latter capacity he was instrumental in founding the European Process Safety Centre in 1992. He has also been chairman of the International Group on Unstable Substances (IGUS) for 10 years, of the European Study Group on Risk Analysis (1980-1985), and of a NATO Group on Explosives (1982-1992). At the Delft University of Technology he led a multinational project on gas explosion fundamentals at elevated pressures and temperatures (2003-2008). In 2007 he co-organized a NATO advanced research workshop on Resilience of Cities to Terrorists and other Threats. From 2004-2012 he was a Member of the Dutch national Advisory Council on Hazardous Substances. Ming Yang is an Assistant Professor in the section of Safety and Security Science at Delft University of Technology. His scientific work evolves around reliability, risk, and resilience modelling to support safety and security-related decision-making problems in the process industries and offshore operations. He holds a B.Eng in Chemical and Material Engineering and minor in Management Science, a MSc. in Environmental System Engineering, and a PhD in Oil and Gas Engineering. He is Associate Editor of ACS Journal of Chemical Health and Safety, Subject Editor of Process Safety and Environmental Protection, Safety in Extreme Environments, Editorial Board Member of Journal of Loss Prevention in the Process Industries, Engineering Applications of Artificial Intelligence, and Hygiene and Environmental Health Advances.

• 1. Opportunities and threats to process safety in digitalized process systems—An overviewHans Pasman, Hao Sun, Ming Yang, and Faisal Khan2. State-of-the-art in process safety and digital system Md Tanjin Amin, Rajeevan Arunthavanathan, Md Alauddin, and Faisal Khan3. Data-driven approaches: Use of digitized operational data in process safety Yiming Bai, Shuaiyu Xiang, Zeheng Zhao, Borui Yang, and Jinsong Zhao4. Industry 4.0 based process data analytics platform Thumeera R. Wanasinghe, Mihiran Galagedarage Don, Rajeevan Arunthavanathan, and Raymond G. Gosine5. Digital process safety managementMark Slezak, Stewart Behie, and Hans Pasman6. Statistical approaches and artificial neural networks for process monitoring Md Alauddin, Rajeevan Arunthavanathan, Md Tanjin Amin, and Faisal Khan7. Alarm management techniques to improve process safetyFan Yang, Jiandong Wang, Mohsen Asaadi, Wenkai Hu, Zhen Wang, and Yinong Zhang8. Performance evaluation of digitalized safety barriers Aibo Zhang and Yiliu Liu9. Dynamic operational risk assessment in process safety management Xinhong Li, Luyao Zhang, Faisal Khan, and Guoming Chen10. Risk of cascading effects in digitalized process systemsMatteo Iaiani, Alessandro Tugnoli, and Valerio Cozzani11. Uncertainty modeling in risk assessment of digitalized process systems Mohammad Yazdi, Esmaeil Zarei, Sidum Adumene, Rouzbeh Abbassi, and Payam Rahnamayiezekavat12. Human factors in digitalized process operationsRajagopalan Srinivasan, Babji Srinivasan, and Mohd Umair Iqbal13. Safety assessment of complex socio-technical systemsNicola Paltrinieri14. Security of digitalized process systemsAhmed Hamdy El-Kady, Syeda Halim, Hans Pasman, and Faisal Khan15. Integrated dynamic risk management in process plantsMohammed Taleb-Berrouane and Hans Pasman16. Use of digital twins for process safety managementArvind Keprate and Nikhil Bagalkot17. Resilience analysis of digitalized process systemsRioshar Yarveisy, Hao Sun, Ming Yang, and Hans Pasman18. Risk assessment in Industry 4.0Md Tanjin Amin and Faisal Khan

Faisal I. Khan is a Chemical Engineering Professor and Director of the Mary Kay O'Connor Process Safety Center and the Ocean Energy Safety Institute (OESI), Texas A&M University. He is the founder of the Centre for Risk Integrity and Safety Engineering (C-RISE), a Fellow of the Canadian Academy of Engineering, the Engineering Institute of Canada, and the Canadian Society of Chemical Engineering. His areas of research interest include offshore safety and risk engineering, inherent safety, risk management, and risk-based integrity assessment and management. Dr. Khan is actively involved with multinational oil and gas industries in addressing safety and asset integrity issues. He also served as the Safety and Risk Advisor to the Government of Newfoundland and Labrador, Canada. He continues to serve as a subject matter expert to many organizations, including Lloyd's Register EMEA, SBM Modco, Intecsea, Technip, and Qatar Gas. He served as a Visiting Professor of Offshore and Marine Engineering at the Australian Maritime College (AMC), University of Tasmania, Australia, where he led the development of the offshore safety and risk engineering group and initiated global engagements with numerous international institutions. Dr. Khan is the recipient of the President's Outstanding Research Award of 2012–13 at Memorial University, the President's Outstanding Research Supervision Award of 2013–14 at Memorial University, the CSChE National Award on Process Safety Management of 2014, and the Society of Petroleum Engineers award for his contribution to Health, Safety, and Risk Engineering. He has authored over 500 research articles in peer-reviewed journals and conferences on safety, risk, and reliability engineering. He has authored five books on the subject area. He is the Editor of the Journal of Process Safety and Environmental Protection, Safety in Extreme Environment, and ASME Part A (Risk and Uncertainty Analysis). He regularly offers training programs/workshops on safety and risk engineering in various locations, including St. John's, Chennai, Dubai, Beijing, Aberdeen, Cape Town, Doha, and Kuala Lumpur. TEES Research Professor, Mary Kay O'Connor Process Safety Center, Texas A&M University, Texas, USA., Emeritus Professor, Chemical Risk Management of the Delft University of Technology, and associated member of the Dutch Council for Life Environment and Infrastructure in the Netherlands. Professor Pasman graduated in Chemical Technology at Delft University of Technology in 1961, and finished a Doctor’s thesis in 1964 while working for Shell. He joined the Dutch Organisation for Applied Research, TNO, in 1965, initiating and performing research in reactive materials, gas, dust and energetic material explosions, investigation of industrial accidents and risk analysis, while also managing organizational units. He has been a member of the Working Party on Loss Prevention and Safety Promotion in the Process Industries since 1972, and chairman from 1986-2004. In this latter capacity he was instrumental in founding the European Process Safety Centre in 1992. He has also been chairman of the International Group on Unstable Substances (IGUS) for 10 years, of the European Study Group on Risk Analysis (1980-1985), and of a NATO Group on Explosives (1982-1992). At the Delft University of Technology he led a multinational project on gas explosion fundamentals at elevated pressures and temperatures (2003-2008). In 2007 he co-organized a NATO advanced research workshop on Resilience of Cities to Terrorists and other Threats. From 2004-2012 he was a Member of the Dutch national Advisory Council on Hazardous Substances. Ming Yang is an Assistant Professor in the section of Safety and Security Science at Delft University of Technology. His scientific work evolves around reliability, risk, and resilience modelling to support safety and security-related decision-making problems in the process industries and offshore operations. He holds a B.Eng in Chemical and Material Engineering and minor in Management Science, a MSc. in Environmental System Engineering, and a PhD in Oil and Gas Engineering. He is Associate Editor of ACS Journal of Chemical Health and Safety, Subject Editor of Process Safety and Environmental Protection, Safety in Extreme Environments, Editorial Board Member of Journal of Loss Prevention in the Process Industries, Engineering Applications of Artificial Intelligence, and Hygiene and Environmental Health Advances.

• 1. Opportunities and threats to process safety in digitalized process systems—An overviewHans Pasman, Hao Sun, Ming Yang, and Faisal Khan2. State-of-the-art in process safety and digital system Md Tanjin Amin, Rajeevan Arunthavanathan, Md Alauddin, and Faisal Khan3. Data-driven approaches: Use of digitized operational data in process safety Yiming Bai, Shuaiyu Xiang, Zeheng Zhao, Borui Yang, and Jinsong Zhao4. Industry 4.0 based process data analytics platform Thumeera R. Wanasinghe, Mihiran Galagedarage Don, Rajeevan Arunthavanathan, and Raymond G. Gosine5. Digital process safety managementMark Slezak, Stewart Behie, and Hans Pasman6. Statistical approaches and artificial neural networks for process monitoring Md Alauddin, Rajeevan Arunthavanathan, Md Tanjin Amin, and Faisal Khan7. Alarm management techniques to improve process safetyFan Yang, Jiandong Wang, Mohsen Asaadi, Wenkai Hu, Zhen Wang, and Yinong Zhang8. Performance evaluation of digitalized safety barriers Aibo Zhang and Yiliu Liu9. Dynamic operational risk assessment in process safety management Xinhong Li, Luyao Zhang, Faisal Khan, and Guoming Chen10. Risk of cascading effects in digitalized process systemsMatteo Iaiani, Alessandro Tugnoli, and Valerio Cozzani11. Uncertainty modeling in risk assessment of digitalized process systems Mohammad Yazdi, Esmaeil Zarei, Sidum Adumene, Rouzbeh Abbassi, and Payam Rahnamayiezekavat12. Human factors in digitalized process operationsRajagopalan Srinivasan, Babji Srinivasan, and Mohd Umair Iqbal13. Safety assessment of complex socio-technical systemsNicola Paltrinieri14. Security of digitalized process systemsAhmed Hamdy El-Kady, Syeda Halim, Hans Pasman, and Faisal Khan15. Integrated dynamic risk management in process plantsMohammed Taleb-Berrouane and Hans Pasman16. Use of digital twins for process safety managementArvind Keprate and Nikhil Bagalkot17. Resilience analysis of digitalized process systemsRioshar Yarveisy, Hao Sun, Ming Yang, and Hans Pasman18. Risk assessment in Industry 4.0Md Tanjin Amin and Faisal Khan

Faisal I. Khan is a Chemical Engineering Professor and Director of the Mary Kay O'Connor Process Safety Center and the Ocean Energy Safety Institute (OESI), Texas A&M University. He is the founder of the Centre for Risk Integrity and Safety Engineering (C-RISE), a Fellow of the Canadian Academy of Engineering, the Engineering Institute of Canada, and the Canadian Society of Chemical Engineering. His areas of research interest include offshore safety and risk engineering, inherent safety, risk management, and risk-based integrity assessment and management. Dr. Khan is actively involved with multinational oil and gas industries in addressing safety and asset integrity issues. He also served as the Safety and Risk Advisor to the Government of Newfoundland and Labrador, Canada. He continues to serve as a subject matter expert to many organizations, including Lloyd's Register EMEA, SBM Modco, Intecsea, Technip, and Qatar Gas. He served as a Visiting Professor of Offshore and Marine Engineering at the Australian Maritime College (AMC), University of Tasmania, Australia, where he led the development of the offshore safety and risk engineering group and initiated global engagements with numerous international institutions. Dr. Khan is the recipient of the President's Outstanding Research Award of 2012–13 at Memorial University, the President's Outstanding Research Supervision Award of 2013–14 at Memorial University, the CSChE National Award on Process Safety Management of 2014, and the Society of Petroleum Engineers award for his contribution to Health, Safety, and Risk Engineering. He has authored over 500 research articles in peer-reviewed journals and conferences on safety, risk, and reliability engineering. He has authored five books on the subject area. He is the Editor of the Journal of Process Safety and Environmental Protection, Safety in Extreme Environment, and ASME Part A (Risk and Uncertainty Analysis). He regularly offers training programs/workshops on safety and risk engineering in various locations, including St. John's, Chennai, Dubai, Beijing, Aberdeen, Cape Town, Doha, and Kuala Lumpur. TEES Research Professor, Mary Kay O'Connor Process Safety Center, Texas A&M University, Texas, USA., Emeritus Professor, Chemical Risk Management of the Delft University of Technology, and associated member of the Dutch Council for Life Environment and Infrastructure in the Netherlands. Professor Pasman graduated in Chemical Technology at Delft University of Technology in 1961, and finished a Doctor’s thesis in 1964 while working for Shell. He joined the Dutch Organisation for Applied Research, TNO, in 1965, initiating and performing research in reactive materials, gas, dust and energetic material explosions, investigation of industrial accidents and risk analysis, while also managing organizational units. He has been a member of the Working Party on Loss Prevention and Safety Promotion in the Process Industries since 1972, and chairman from 1986-2004. In this latter capacity he was instrumental in founding the European Process Safety Centre in 1992. He has also been chairman of the International Group on Unstable Substances (IGUS) for 10 years, of the European Study Group on Risk Analysis (1980-1985), and of a NATO Group on Explosives (1982-1992). At the Delft University of Technology he led a multinational project on gas explosion fundamentals at elevated pressures and temperatures (2003-2008). In 2007 he co-organized a NATO advanced research workshop on Resilience of Cities to Terrorists and other Threats. From 2004-2012 he was a Member of the Dutch national Advisory Council on Hazardous Substances. Ming Yang is an Assistant Professor in the section of Safety and Security Science at Delft University of Technology. His scientific work evolves around reliability, risk, and resilience modelling to support safety and security-related decision-making problems in the process industries and offshore operations. He holds a B.Eng in Chemical and Material Engineering and minor in Management Science, a MSc. in Environmental System Engineering, and a PhD in Oil and Gas Engineering. He is Associate Editor of ACS Journal of Chemical Health and Safety, Subject Editor of Process Safety and Environmental Protection, Safety in Extreme Environments, Editorial Board Member of Journal of Loss Prevention in the Process Industries, Engineering Applications of Artificial Intelligence, and Hygiene and Environmental Health Advances.

• 1. Opportunities and threats to process safety in digitalized process systems—An overviewHans Pasman, Hao Sun, Ming Yang, and Faisal Khan2. State-of-the-art in process safety and digital system Md Tanjin Amin, Rajeevan Arunthavanathan, Md Alauddin, and Faisal Khan3. Data-driven approaches: Use of digitized operational data in process safety Yiming Bai, Shuaiyu Xiang, Zeheng Zhao, Borui Yang, and Jinsong Zhao4. Industry 4.0 based process data analytics platform Thumeera R. Wanasinghe, Mihiran Galagedarage Don, Rajeevan Arunthavanathan, and Raymond G. Gosine5. Digital process safety managementMark Slezak, Stewart Behie, and Hans Pasman6. Statistical approaches and artificial neural networks for process monitoring Md Alauddin, Rajeevan Arunthavanathan, Md Tanjin Amin, and Faisal Khan7. Alarm management techniques to improve process safetyFan Yang, Jiandong Wang, Mohsen Asaadi, Wenkai Hu, Zhen Wang, and Yinong Zhang8. Performance evaluation of digitalized safety barriers Aibo Zhang and Yiliu Liu9. Dynamic operational risk assessment in process safety management Xinhong Li, Luyao Zhang, Faisal Khan, and Guoming Chen10. Risk of cascading effects in digitalized process systemsMatteo Iaiani, Alessandro Tugnoli, and Valerio Cozzani11. Uncertainty modeling in risk assessment of digitalized process systems Mohammad Yazdi, Esmaeil Zarei, Sidum Adumene, Rouzbeh Abbassi, and Payam Rahnamayiezekavat12. Human factors in digitalized process operationsRajagopalan Srinivasan, Babji Srinivasan, and Mohd Umair Iqbal13. Safety assessment of complex socio-technical systemsNicola Paltrinieri14. Security of digitalized process systemsAhmed Hamdy El-Kady, Syeda Halim, Hans Pasman, and Faisal Khan15. Integrated dynamic risk management in process plantsMohammed Taleb-Berrouane and Hans Pasman16. Use of digital twins for process safety managementArvind Keprate and Nikhil Bagalkot17. Resilience analysis of digitalized process systemsRioshar Yarveisy, Hao Sun, Ming Yang, and Hans Pasman18. Risk assessment in Industry 4.0Md Tanjin Amin and Faisal Khan