Metalloprotein Active Site Assembly

Inbunden, Engelska, 2017

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Summarizes the essential biosynthetic pathways for assembly of metal cofactor sites in functional metalloproteinsMetalloprotein Active Site Assembly focuses on the processes that have evolved to orchestrate the assembly of metal cofactor sites in functional metalloproteins. It goes beyond the simple incorporation of single metal ions in a protein framework, and includes metal cluster assembly, metal-cofactor biosynthesis and insertion, and metal-based post-translational modifications of the protein environments that are necessary for function. Several examples of each of these areas have now been identified and studied; the current volume provides the current state-of-the-art understanding of the processes involved.An excellent companion to the earlier book in this series Metals in Cells—which discussed both the positive and negative effects of cellular interactions with metals—this comprehensive book provides a diverse sampling of what is known about metalloprotein active site assembly processes. It covers all major biological transition metal components (Mn, Fe, Co, Ni, Mo), as well as the other inorganic components, metal-binding organic cofactors (e.g., heme, siroheme, cobalamin, molybdopterin), and post-translationally modified metal binding sites that make up the patchwork of evolved biological catalytic sites. The book compares and contrasts the biosynthetic assembly of active sites involving all biological metals. This has never been done before since it is a relatively new, fast-developing area of research.Metalloprotein Active Site Assembly is an ideal text for practitioners of inorganic biochemistry who are studying the biosynthetic pathways and gene clusters involved in active site assembly, and for inorganic chemists who want to apply the concepts learned to potential synthetic pathways to active site mimics.

Produktinformation

Utgivningsdatum2017-10-06
Mått222 x 280 x 24 mm
Vikt1 361 g
FormatInbunden
SpråkEngelska
SerieEIC Books
Antal sidor424
FörlagJohn Wiley & Sons Inc
ISBN9781119159834

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Biokemi inom Naturvetenskap och teknik

Contributors ixSeries Preface xiiiVolume Preface xvPart 1: Assembly and Trafficking of Simple Fe-S Clusters 1Nif System for Simple [Fe–S] Cluster Assembly in Nitrogen-Fixing Bacteria 3Patricia C. Dos Santos and Dennis R. DeanIron–Sulfur Cluster Assembly in Bacteria and Eukarya using the ISC Biosynthesis Machinery 17Sandrine Ollagnier de Choudens and Hélène PuccioThe Suf System in Archaea, Bacteria, and Eukaryotic Organelles 37Guangchao Dong, Savannah Witcher, F. Wayne Outten and Marinus PilonRoles of Class II Glutaredoxins in the Maturation of Fe–S Proteins 53Jonathan Przybyla-Toscano, Thomas Roret, Jérémy Couturier and Nicolas RouhierPart 2: Assembly of Complex and Heterometallic Fe-S Cluster Active Sites 73Nitrogenase Metallocluster Assembly 75Nathaniel S. Sickerman, Lee A. Rettberg, Yilin Hu and Markus W. RibbeMetallocluster Assembly: Maturation of [FeFe]-Hydrogenases 93Giorgio Caserta, Ludovic Pecqueur, Cecilia Papini and Marc FontecaveCO Dehydrogenase and Acetyl-CoA Synthase 111Holger DobbekPart 3: Assembly of Homometallic and Heterometalic Cu Cluster Active Sites 123Assembly of Dinuclear Copper Center in Tyrosinases and Hemocyanins 125Nobutaka Fujieda and Shinobu ItohMulticopper Oxidases 139Daniel J. KosmanAssembly of the Redox-Active Metal Centers of Cytochrome c Oxidase 157Eva Nyvltova, Antoni Barrientos and Jonathan HoslerCuA and CuZ Center Assembly in Nitrous Oxide Reductase 185Sofia R. Pauleta and Isabel MouraMoCu CO Dehydrogenase and its Active-Site Assembly 197Frank MickoleitPart 4: Assembly of Homometallic and Heterometallic Mn Clusters 213Homo- and Heterometallic Dinuclear Manganese Proteins: Active Site Assembly 215Gustav Berggren, Daniel Lundin and Britt-Marie SjöbergBiogenesis and Assembly of the CaMn4O5 Core of Photosynthetic Water Oxidases and Inorganic Mutants 233Colin Gates, Gennady Ananyev and G. Charles DismukesPart 5: Assembly of Homometallic and Heterometallic Ni Clusters 249Urease Activation 251Robert P. HausingerInsights into [NiFe]-Hydrogenase Active Site Metallocluster Assembly 261Robert Gary Sawers and Constanze PinskePart 6: Assembly of Cofactors for Binding Active-Site Metal Centers 273Moco in Mo/W Enzymes 275Silke LeimkühlerHeme Biosynthesis 299Amy E. Medlock and Harry A. DaileySiroheme Assembly and Insertion to Nitrite and Sulfite Reductase 315M. Elizabeth Stroupe and Martin J. WarrenBiosynthesis of Coenzyme F430 and the Posttranslational Modification of the Active Site Region of Methyl-Coenzyme M Reductase 323Steven O. Mansoorabadi, Kaiyuan Zheng and Phong D. NgoCoenzyme B12 Biosynthesis in Bacteria and Archaea 335Theodoric A. Mattes, Jorge C. Escalante-Semerena, Evelyne Deery and Martin J. WarrenCrosslinked Cys–Tyr Free Radical Redox Cofactor 361James W. WhittakerTopaquinone Biogenesis and Lysyl Tyrosine Quinone Biogenesis in Cu Amine Oxidases 375David M. Dooley, Doreen E. Brown and Eric M. ShepardIndex 389