Del i serien Metal Ions in Life Sciences

Metal-Carbon Bonds in Enzymes and Cofactors

Inbunden, Engelska, 2015

AvAstrid Sigel,Helmut Sigel,Roland K.O. Sigel

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The occurrence of a wide variety of metal-carbon bonds in living organisms, ranging from bacteria to humans, is only recently recognized. Of course, the historical examples are the B12 coenzymes containing cobalt-carbon bonds, but now such bonds are also known for nickel, iron, copper, and other transition metal ions. There is no other comparable book; MILS-6, written by 17 experts, summarizes the most recent insights into this fascinating topic.

Produktinformation

Utgivningsdatum2015-07-20
Mått155 x 235 x 34 mm
Vikt938 g
FormatInbunden
SpråkEngelska
SerieMetal Ions in Life Sciences
Antal sidor530
Upplaga15001
FörlagDe Gruyter
ISBN9783110442793

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From the Content:• Organometallic Chemistry of B12 Coenzymes• Cobalamin- and Corrinoid-Dependent Enzymes• Nickel-Alkyl Bond Formation in the Active Site of Methyl-Coenzyme M Reductase• Nickel-Carbon Bonds in Acetyl-Coenzyme A Synthases/Carbon Monoxide Dehydrogenases• Structure and Function of [NiFe]-Hydrogenases• Carbon Monoxide and Cyanide Ligands in the Active Site of [FeFe]-Hydrogenases• Carbon Monoxide as Intrinsic Ligand to Iron in the Active Site of [Fe]-Hydrogenase• The Dual Role of Heme as Cofactor and Substrate in the Biosynthesis of Carbon Monoxide• Copper-Carbon Bonds in Mechanistic and Structural Probing of Proteins as well as in Situations where Copper Is a Catalytic or Receptor Site• Interaction of Cyanide with Enzymes Containing Vanadium, Manganese, Non-Heme Iron, and Zinc• The Reaction Mechanism of the Molybdenum Hydroxylase Xanthine Oxidoreductase: Evidence Against the Formation of Intermediates Having Metal-Carbon Bonds• Computational Studies of Biooganometalllic Enzymes and Cofactors