Metabotropic Glutamate Receptor Technologies

Inbunden, Engelska, 2021

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This volume highlights various techniques used to study multiple aspects of mGlu receptor function.

Produktinformation

Technologies for Screening of mGlu Receptor Allosteric Modulators.- Positron Emission Tomography (PET) Imaging of Metabotropic Glutamate Receptor Subtype 2 (mGlu2) Based on a Negative Allosteric Modulator Radioligand.- PET Imaging of Type 5 Metabotropic Glutamate Receptors.- Electrophysiological and Calcium Imaging Approaches to Study Metabotropic Glutamate Receptors.- Role of Metabotropic Glutamate Receptors (mGluRs) in the Regulation of Intracellular Calcium Signaling: Theory, Protocols, and Data Analysis.- Optical Approaches for Modulating mGlu Receptor Activity.- Classic and Modern Approaches to Investigating Interactions between Dopamine Systems and Metabotropic Glutamate Receptors.- Using Western Blotting for the Evaluation of Metabotropic Glutamate Receptors within the Nervous System: Procedures and Technical Considerations.- Investigation of mGlu Receptor Cell Surface Trafficking in Acute Brain Slices Using Biotinylation.- Co-Labeling of Neuronal Cells using DiI Neuronal Filling and Immunohistochemistry to Explore Metabotropic Glutamate Receptor Expression.- Fluorescence Immunohistochemistry Techniques for Labelling Metabotropic Glutamate Receptors in the Central Nervous System.- Multiplex Arrays for Quantifying Relative Levels of Cytokines in Brain Tissue Lysates: Implications for mGlu Receptor Mediated Alterations.- mGlu Receptor Modulation in Murine Models of Stress and Affective Disorders.- Role of Metabotropic Glutamate Receptors in Alcohol Drinking Behaviors.