Metabolic Pathway Design

Pablo Carbonell is a senior staff scientist at the SynBioChem Centre, Manchester Institute of Biotechnology. His field of research is automated design for metabolic engineering and synthetic biology. Pablo has developed several bioretrosynthesis-based pathway design tools, including RetroPath, XTMS, EcoliTox, Selenzyme for enzyme selection and Promis for protein design. He is interested in applying the principles of machine learning and control engineering to sustainable biological design. He has contributed to the development of several theoretical models for bio-based, bionics systems – from biosensors to robotic exoskeletons.

• Part I. Metabolic Pathway Modeling.- Getting on the Path to Engineering Biology.- Genome-Scale Modeling.- Pathway Modeling.- Modeling Chemical Diversity.- Part II. Metabolic Pathway Discovery.- Enzyme Discovery and Selection.- Pathway Discovery.- Pathway Selection.- Part III. Metabolic Pathway Design.- Pathway Design.- Pathway Redesign.