Metabolic Neuropsychiatry

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Inbunden, Engelska, 2025

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This open access book provides an interdisciplinary perspective on energy metabolism in the brain and body in neuropsychiatric disorders and suggests future research directions.Multiple lines of evidence indicate that energy metabolism is aberrant in the body and brain in individuals with major neuropsychiatric disorders such as schizophrenia, mood disorders, and neurodegenerative disorders. Emerging therapeutic interventions aim to improve outcomes in many of these common and severe disorders. To foster interdisciplinary dialogue and to promote informed applications in research, medicine, and public health, the Ernst Strüngmann Forum convened scholars from diverse fields to examine the role of energy metabolism in brain function, the bidirectional association between metabolism in the brain and body, and the future therapeutic potential of treatment interventions that improve metabolism in people with psychiatric disorders.Synthesizing the interdisciplinary perspectives that emerged from these discussions, the book is organized in four sections:Role of Metabolism in Brain FunctionMetabolic Abnormalities in Neuropsychiatric DisordersSystemic Metabolic Aspects of Neuropsychiatric DisordersMetabolism-Based TherapiesThis volume offers insights to researchers and clinicians working in basic, translational, and clinical research in neurology and psychiatry pertinent to mitochondrial function, energy metabolism, human physiology, and treatment development.

Produktinformation

Utgivningsdatum2025-10-04
Mått155 x 235 x 25 mm
Vikt686 g
FormatInbunden
SpråkEngelska
SerieStrüngmann Forum Reports
Antal sidor333
FörlagSpringer Nature Switzerland AG
ISBN9783032056290

Tillhör följande kategorier

Biologisk psykologi och neuropsykologi inom Psykologi och pedagogik
Fysiologi inom Medicin
Endokrinologi inom Medicin
Psykiatri inom Medicin
Biovetenskap inom Naturvetenskap och teknik
Biokemi inom Naturvetenskap och teknik

Dost Öngür: A native of Istanbul, Turkey, Dr. Öngür obtained his M.D./Ph.D. degree from Washington University in St. Louis and psychiatric residency training at the MGH/McLean Adult Psychiatry program. He is currently the William P. and Henry B. Test Professor of Psychiatry at Harvard Medical School and Chief of the Psychotic Disorders Division at McLean Hospital. Dr. Öngür’s research uses neuroimaging approaches to probe brain abnormalities in psychotic disorders as well as clinical studies to understand the trajectories of illness in early phases of these disorders. His work has been continuously funded by the NIH and other sources for over two decades, including a current P50 Center grant focused on early psychosis research. His work using magnetic resonance spectroscopy has documented extensive bioenergetic abnormalities in the brain in schizophrenia and bipolar disorder. He is also an active clinician and an administrator responsible for all clinical services serving patients with psychotic disorders at McLean.Dr. Öngür has won awards from McLean Hospital and Harvard Medical School for his teaching and mentoring, and the Kempf and Gralnick Awards from the APA. He has served on Council for professional organizations such as the ACNP, SOBP and SIRS, and serves on the Scientific Council for NARSAD/BBRF. Most recently, he was elected to serve as President for SOBP during 2026-2027. Finally, since 2018 he is the Editor in Chief of JAMA Psychiatry, a premier journal in the field.Judith M. Ford: Dr. Ford obtained her Ph.D. in Neuroscience from Stanford University School of Medicine in Stanford, California. She served on the faculty of Psychiatry and Behavioral Sciences at Stanford until 2004, when she left to join the Psychiatry faculty at Yale University School of Medicine. In 2007, she returned to California to join the Psychiatry faculty at the University of California San Francisco.Dr. Ford’s research uses neuroimaging, including EEG, to understand the biological basis of psychotic disorders. Her work has been continuously funded by the NIH and, more recently, by the Veterans Administration. Her most recent NIH grant funds a mechanistic clinical trial asking if neural network instability in schizophrenia and psychotic bipolar disorder can be improved with a very low carbohydrate ketogenic diet.Dr. Ford won the Middleton Award from the Veterans Administration for her basic neuroscience work elucidating the pathophysiology of serious mental illnesses and the lifetime achievement award from the Society for Psychophysiological Research. She has served on councils for professional organizations such as the ACNP and SOBP, and currently serves on SOBP Council as Past President and on the Board of Directors for the International Organization of Psychophysiology. Since 2007, she has served on the Scientific Council for NARSAD/BBRF, she co-chairs the Young Investigator grant program, and recently became President of the BBRF Scientific Council. She is on the editorial boards of Schizophrenia Bulletin, Biological Psychiatry: Cognitive Neuroscience, and Neuroimage Clinical.

1. Metabolic Neuropsychiatry.- 2. Integrating Brain Metabolism Research into Big Data Human Neuroscience.- 3. Brain Energy Constraints and Vulnerability.- 4. Brain Energy Production: Vulnerability and Pathophysiology.- 5. What Is the Best Evidence for Bioenergetic Abnormalities in Severe Mental Illness?.- 6. Role of Metabolism in the Emergence of Neuropsychiatric Disorders.- 7. Systemic Mitochondrial Alterations in Alzheimer’s Disease Dementia.- 8. Metabolic Abnormalities in Psychiatric Disorders: A Transdiagnostic, Whole-Body Approach.- 9. Links between Inflammation and Metabolism in Periphery and Brain: Lessons from Epidemiological Research on Depression.- 10. Metabolic Measures across the Lifespan: Implications for Body and Mind.- 11. Severe Mental Illness As a Multisystem Metabolic Disorder: From Brain to Body and Back Again.- 12. Best Practices for Randomized Controlled Trials in Metabolic Neuropsychiatry Studies.- 13. Disassociating Causality in Complex Interacting Systems.- 14. Designing Innovative Interventions for Metabolic Psychiatry.