Mesenchymal Stem Cells and Skeletal Regeneration

Häftad, Engelska, 2013

AvPeter Giannoudis,Elena Jones,Xuebin Yang,Dennis McGonagle

349 kr

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This book covers our current understanding of the role of mesenchymal stem cells (MSCs) and other mesenchymal progenitors in skeletal regeneration, encompassing bone, cartilage and whole joint regeneration. The expansion reflects developments in the field to include data on the use of MSCs in drug development, growth factors, scaffolds and biomechanical manipulations for skeletal trauma and diseases, including osteoporosis and arthritis.Written for an audience of clinicians and young researchers who are exposed to MSCs in their work, this work summarizes recent findings pertaining to the definition and characterization of MSCs in skeletal tissues and discusses the mechanisms of their actions in regeneration of bone in vivo. The authors describe recent findings pertaining to the efficacy of MSC therapies in animal models and in human clinical trials and bring together literature showing that the ways MSCs are extracted, expanded and implanted can considerably affect bone formation outcomes. Finally, it presents the latest knowledge on the nature of native MSCs in skeletal tissues, which provide a platform for novel in situ tissue regeneration approaches for systemic bone disease such as osteoporosis.

Produktinformation

Utgivningsdatum2013-03-04
Mått152 x 229 x 4 mm
Vikt110 g
FormatHäftad
SpråkEngelska
Antal sidor70
FörlagElsevier Science Publishing Co Inc
ISBN9780124079151

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Muskuloskeletala sjukdomar inom Medicin

Chapter 1. Current Strategies for Skeletal Regeneration in the Early Twenty-First Century1.1 The Economic and Social Burden of Diseases Affecting Bone and Cartilage1.2 Current Clinical Approaches for Bone Regeneration: The Diamond ConceptChapter 2. Mesenchymal Stem Cells: Discovery in Bone Marrow and Beyond2.1 Discovery2.2 “Explosion of Interest in MSCs2.3 MSC Tissue HeterogeneityChapter 3. Traditional Bone Tissue Engineering Using MSCs3.1 Proof-of-Principle Experiments in Animal Models3.2 Cell Therapy Using MSCs3.3 Bone Tissue Engineering3.4 Serum-Free MSC Expansion3.5 Osteochondral Tissue RepairChapter 4. Challenges for Cartilage Regeneration4.1 Osteoarthritis (OA) Development and the Loss of Cartilage4.2 Current Cartilage Repair Strategies4.3 Spontaneous Cartilage Repair4.4 Harnessing the Potential of Synovial Fluid MSCs for Cartilage Repair ApplicationsChapter 5. Animal Models for Investigating MSC Involvement in Bone and Cartilage Repair5.1 Small Animal Models5.2 Large Animal Models for Bone Repair and Regeneration5.3 Animal Models for Osteochondral Tissue Engineering5.4 Animal Models for Cartilage Tissue EngineeringChapter 6. Native MSCs6.1 MSCs and Marrow Reticular Cells6.2 Nonadherent MSCs6.3 Solid Tissues: MSCs and Fibroblasts6.4 MSC as a PericyteChapter 7. “Trophic Actions of MSCs7.1 Discovery of the Trophic Action of MSCs in Cardiac Repair Trials7.2 Other Disease ApplicationsChapter 8. Novel Approaches for Bone Regeneration Targeting Native MSCs8.1 Medical Devices Allowing MSC Concentration8.2 Host MSC “Modifiers8.3 “In vivo Bioreactors and Periosteum-Like Membranes8.4 Targeting MSCs in Systemic Bone Diseases: Novel Bone AnabolicsConcluding RemarksReferences

"Mesenchymal Stem Cells and Skeletal Regeneration. By Elena A. Jones, Xuebin Yang, Peter Giannoudis, and Dennis McGonagle. Academic Press. Amsterdam (The Netherlands) and Boston (Massachusetts): Elsevier. $29.95 (paper). vi 66 p.; ill.; no index. ISBN: 978-0-12-407915-1. 2013." - The Quarterly Review of Biology,September 2014"Researchers in the fields of musculoskeletal disease and molecular medicine, tissue engineering, and trauma and orthopedic surgery discuss how mesenchymal stem cells offer advantages over current clinical approaches for bone regeneration, animal models with MSCs, and remaining challenges. The concise monograph includes a summary table of clinical trials…"--Reference and Research Book News, August 2013