In this issue of Physical Medicine and Rehabilitation Clinics, guest editors Drs. Lisa A. Brenner and Ryan Holliday bring their considerable expertise to the topic of Mental Health in Rehabilitation: Across the Lifespan. In the evolving landscape of medicine, integrating mental health into rehabilitation practices reflects a shift toward truly patient-centered, multidisciplinary care, not only to optimize physical recovery but also to foster psychological resilience, social integration, and overall well-being. In this issue, top experts discuss key issues in this area, including evidence-based psychotherapies such as problem-solving therapy and trauma-focused intervention.