Membrane Proteins

Rossen Donev received his PhD degree in 1999 from the Institute of Molecular Biology, Bulgarian Academy of Sciences. He did postdoctoral training at Imperial Cancer Research Fund, UK (renamed after the merger with Cancer Research Campaign to Cancer Research UK, London Research Institute) and Cardiff University. In 2007 he was awarded a New Investigator Grant Award from the Medical Research Council (UK) to establish himself as an independent Principle Investigator. In 2010 Dr. Donev was appointed Senior Lecturer at Swansea University. In 2016 Dr. Donev joined MicroPharm Ltd (UK) where currently he is Head of Research. He has published more than 60 research papers, chaired scientific meetings and given invited plenary talks. Rossen Donev has consulted on projects related to development of treatments for neurodevelopmental disorders and cancer therapies. He serves as Editor-in-Chief of the Advances in Protein Chemistry and Structural Biology and on editorial board of several other journals. His research interests include signaling pathways involved in neuropsychiatric disorders and tumor escape from the immune system, and development of therapeutic strategies for their treatment. More recently he has focused on development of immunotherapeutics for non-systemic applications.

• 1. Architects of their own environment: How membrane proteins shape the Gram-negative cell envelope Johannes Thoma and Bj€orn M. Burmann2. Modulation of host cellular responses by gram-negative bacterial porins Arpita Sharma, Shashi Prakash Yadav, Dwipjyoti Sarma, and Arunika Mukhopadhaya3. Pore formation by pore forming membrane proteins towards infections Achinta Sannigrahi and Krishnananda Chattopadhyay4. Transmembrane β-barrel proteins of bacteria: From structure to function Simen Hermansen, Dirk Linke, and Jack C. Leo5. Ribosome-membrane crosstalk: Co-translational targeting pathways of proteins across membranes in prokaryotes and eukaryotes Krishnamoorthi Srinivasan, Aneek Banerjee, Priya Baid, Ankit Dhur, and Jayati Sengupta6. Mechanisms of long-distance allosteric couplings in proton-binding membrane transporters Ana-Nicoleta Bondar7. Structures and functions of the membrane-damaging pore-forming proteins Anish Kumar Mondal and Kausik Chattopadhyay8. Ganglioside binding domains in proteins: Physiological and pathological mechanisms Fodil Azzaz, Nouara Yahi, Coralie Di Scala, Henri Chahinian, and Jacques Fantini9. Development of enhanced conformational sampling methods to probe the activation landscape of GPCRs Ravinder Abrol, Erik Serrano, and Luis Jaimes Santiago10. Molecular determinants of GPCR pharmacogenetics: Deconstructing the population variants in β2-adrenergic receptor Manali Joshi, Siddhanta V. Nikte, and Durba Sengupta11. The role of membranes in function and dysfunction of intrinsically disordered amyloidogenic proteins Bani Kumar Pathak, Sandip Dey, Sukanya Mozumder, and Jayati Sengupta12. Dendritic spine membrane proteome and its alterations in autistic spectrum disorder Ana Sofía Vall>es and Francisco J. Barrantes