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Contents: Gérard Jaouen, Nils Metzler-Nolte : Introduction ; Stéphane GIBAUD and Gérard JAOUEN: Arsenic - based drugs: from Fowler’s solution to modern anticancer chemotherapy; Ana M. Pizarro, Abraha Habtemariam and Peter J. Sadler : Activation Mechanisms for Organometallic Anticancer Complexes; Angela Casini, Christian G. Hartinger, Alexey A. Nazarov, Paul J. Dyson : Organometallic antitumour agents with alternative modes of action; Elizabeth A. Hillard, Anne Vessières, Gerard Jaouen : Ferrocene functionalized endocrine modulators for the treatment of cancer; Megan Hogan and Matthias Tacke : Titanocenes – Cytotoxic and Anti-Angiogenic Chemotherapy Against Advanced Renal-Cell Cancer; Seann P. Mulcahy and Eric Meggers : Organometallics as Structural Scaffolds for Enzyme Inhibitor Design; Christophe Biot and Daniel Dive : Bioorganometallic Chemistry and Malaria; Nils Metzler-Nolte : Biomedical applications of organometal-peptide conjugates; Roger Alberto : Organometallic Radiopharmaceuticals; Brian E. Mann : Carbon Monoxide – an essential signaling molecule.
Arsenic-Based Drugs: From Fowler’s Solution to Modern Anticancer Chemotherapy.- Activation Mechanisms for Organometallic Anticancer Complexes.- Organometallic Antitumour Agents with Alternative Modes of Action.- Ferrocene Functionalized Endocrine Modulators as Anticancer Agents.- Titanocenes: Cytotoxic and Anti-angiogenic Chemotherapy Against Advanced Renal-Cell Cancer.- Organometallics as Structural Scaffolds for Enzyme Inhibitor Design.- Bioorganometallic Chemistry and Malaria.- Biomedical Applications of Organometal–Peptide Conjugates.- Organometallic Radiopharmaceuticals.- Carbon Monoxide: An Essential Signalling Molecule.
From the reviews: "Edited by Gerard Jaouen and Nils Metzler-Nolte, this book describes recent advances in the design, synthesis, mechanistic understanding and medical application of organometallic compounds. ... Overall this is an informative book and will be welcomed by those working in the field of inorganic medicinal chemistry." (Simon P. Fricker, Platinum Metals Reviews, Vol. 55 (4), October, 2011)
