Medicinal Chemistry of Nucleic Acids

LI-HE ZHANG is President of the academic committee of State Key Laboratory of Natural and Biomimetic Drugs, as well as Professor of Medicinal Chemistry at Peking University. He is also a member of the Chinese Academy of Sciences, Fellow of the Royal Society of Chemistry, former vice president of the Chinese Pharmaceutical Association, and past president of the Asian Federation of Medicinal Chemistry. ZHEN XI, PhD, is Deputy Director of the State Key Laboratory of Elemento-organic Chemistry, as well as Professor of Pesticide Science and Chemical Biology, and Vice Dean of the College of Chemistry at Nankai University. He holds seven patents and has written a number of reviews and book chapters and sixty-four original research articles.JYOTI CHATTOPADHYAYA, PhD, DSc, is the University Chair of Bioorganic Chemistry and the chair of the Chemical Biology Program at Uppsala University. He is a guest professor of chemistry at both Jilin University and Nankai University. He has written over 410 peer-reviewed original research articles and is also on the editorial boards of several international journals.

• FOREWORD vii CONTRIBUTORS xiINTRODUCTION xv1 RECENT ADVANCES IN CARBOCYCLIC NUCLEOSIDES: SYNTHESIS AND BIOLOGICAL ACTIVITY 1Jianing Wang, Ravindra K. Rawal, and Chung K. Chu2 STRUCTURES AND FUNCTIONS OF NUCLEIC ACIDS MODIFIED WITH S, Se, AND Te AND COMPLEXED WITH SMALL MOLECULES 101Wen Zhang, Jia Sheng, and Zhen Huang3 UNRAVELING OF THE NAD CYCLIZING AND CALCIUM SIGNALING FUNCTIONS OF HUMAN CD38 142Hon Cheung Lee4 DNA AND RNA BINDING SMALL MOLECULES 164Shibo Li and Zhen Xi5 G-QUADRUPLEX DNA AND ITS LIGANDS IN ANTICANCER THERAPY 206Zhi-Shu Huang, Jia-Heng Tan, Tian-Miao Ou, Ding Li, and Lian-Quan Gu6 MOLECULAR MODELING IN NUCLEIC ACID-TARGETED DRUG DESIGN 258Lidan Sun, Hongwei Jin, Liangren Zhang, and Lihe Zhang7 STRUCTURE OF 10–23 DNAzyme IN COMPLEX WITH THE TARGET RNA IN SILICO—A PROGRESS REPORT ON THE MECHANISM OF RNA CLEAVAGE BY DNA ENZYME 272Oleksandr Plashkevych and Jyoti Chattopadhyaya8 LABELING OLIGONUCLEOTIDES TOWARD THE BIOMEDICAL PROBE 292Il Joon Lee and Byeang Hyean Kim9 LOCKED NUCLEIC ACID OLIGONUCLEOTIDES TOWARD CLINICAL APPLICATIONS 335Rakesh N. Veedu and Jesper Wengel10 THE PHARMACOKINETICS RESEARCH OF NUCLEIC ACID DRUGS 349Shengqi Wang, Dandan Lu, Qingqing Wang, Haifeng Song, Chan Gao, Caihong Liu, and Ying Wang11 INDUCIBLE RNAi AND DRUG TARGET VALIDATION 390Wei Xiong, Jing Zhao, Yufan Zhang, Jinxi Wang, Yong-Xiang Zheng, Qiu-Chen He, Li-He Zhang, and De-Min Zhou12 siRNA: THE SPECIFICITY AND OFF-TARGET EFFECTS 405Quan Du, Huang Huang, and Zicai LiangINDEX 423

“The book gives a good overview on some aspects of current research in the field. ... For those in the field seeking inspiration, it is a good book.”  (ChemMedChem, 2012)