Mechanisms in B-Cell Neoplasia 1992

Workshop at the National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, April 21–23, 1992

Häftad, Engelska, 2011

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Main topics covered: B-Cell Development; Immunoglobulin Gene Rearrangement; Multiple Myeloma, Plasmactomas; Lymphomas: B-CLL, Folli- cular Lymphomas BCL-2, BCL-1; Lymphomas: EBV, AIDS Associa- ted Lymphomas; Oncogenes and Transcriptional Factors (text to follow)

Produktinformation

Utgivningsdatum2011-12-21
Mått155 x 235 x 29 mm
Vikt791 g
FormatHäftad
SpråkEngelska
SerieCurrent Topics in Microbiology and Immunology
Antal sidor499
FörlagSpringer-Verlag Berlin and Heidelberg GmbH & Co. KG
ISBN9783642776359

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Onkologi inom Medicin
Biologi inom Naturvetenskap och teknik

B-Cell Development.- Progenitor and Precursor B Lymphocytes of Mice. Proliferation and Differentiation In Vitro and Population, Differentiation and Turnover in SCID Mice In Vivo of Normal and Abnormal Cells.- Isolation and Characterization of a Stromal Cell Line.- Growth and Differentiation of a Bipotent Precursor of B Cells and Macrophages.- Control of Intramarrow B-Cell Genesis by Stromal Cell-Derived Molecules.- Establishment of a Reproducible Culture Technique for the Selective Growth of B-Cell Progenitors.- Multiple Steps in the Regulation and Dysregulation of B-Cell Precursors in the Bone Marrow: c-myc Expression, In Vivo Effects of Interleukins 1 and 7, and Stromal Cell Interactions.- The Purification of B-Cell Precursors From Mouse Fetal Liver.- BCR/ABL Enhances Growth of Multipotent Progenitor Cells But Does Not Block Their Differentiation Potential In Vitro.- Repopulation of SCID Mice with Fetal-Derived B-Lineage Cells.- Early B-Cell Repertoires.- In Vitro Growth and Maturation of Human B-Cell Precursors.- Modulation of Signal Transduction in Phosphocholine-Specific B cells from ?? Transgenic Mice.- Immunoglobulin Gene Rearrangement.- Activities Involved in V(D)J Recombination.- Double-Strand Breaks Associated with V(D)J Recombination at the TCR? Locus in Murine Thymocytes.- Replication, Transcription, CpG Methylation and DNA Topology in V(D)J Recombination.- Rearrangement and Expression of Immunoglobulin Genes in Transgenic Mice.- Regulation of Switch Recombination to the Murine ? 1 Gene.- Protein Recognition Motifs of S? 3 DNA Are Statistically Correlated with Switch Recombination Breakpoints.- Regulation of Transcription of the Germline Immunoglobulin ? Constant Region Gene.- S?BP/BSAP/NF-S? B1, a Murine and Human B-Cell Stage Specific NuclearFactor with DNA Binding Specificity Implying Roles in Switch-Recombination and Transcription.- Multiple Myeloma, Plasmacytomas.- Multidrug Resistance of a Continuously Differentiating Monoclonal B Lineage in the Blood and Bone Marrow of Patients with Multiple Myeloma.- Expression of Multiple Adhesion Molecules on Circulating Monoclonal B Cells in Myeloma.- Circulating Peripheral Blood Plasma Cells in Multiple Myeloma.- Circulating B Lymphocytes in Multiple Myeloma Patients Contain an Autocrine IL-6 Driven Pre-Myeloma Cell Population.- In Which Cells Does Neoplastic Transformation Occur in Myelomatosis?.- Differential Expression of c-myc-mRNA and c-MYC-Protein During Terminal Neoplastic B-Cell Differentiation.- Genes Expressed Selectively in Plasmacytomas: Markers of Differentiation and Transformation.- PCS, a Gene Related to the Immunoglobulin Super Family of Axonal Glycoproteins is Expressed in Murine Plasma Cell Tumors.- Inhibiting IL-6 in Human Multiple Myeloma.- Pathophysiology of Human Multiple Myeloma- Recent Advances and Future Directions.- An Exceptional Mouse Plasmacytoma with a New Kappa/N-myc [T(6; 12) (C1 ; B)] Translocation Expresses N-myc But Not c-myc.- Experimental Model of Human Light-Chain-Associated Disease.- Lymphomas: B-CLL, Follicular Lymphomas BCL-2, BCL-1.- On the Role of Endogenously Produced TNF-? and IL-6 as Regulators of Growth and Differentiation of B-Type Chronic Lymphocytic Leukemia Cells in Vitro.- BCL-2 in B-Chronic Lymphocytic Leukemia.- Subcellular Localization of BCL-2 Protein.- Collaboration of PIM-1 and BCL-2 in Lymphomagenesis.- The Role of bcl-2 in Lymphoid Differentiation and Neoplastic Transformation.- Evolution of Leukemic Heterogeneity of Human B-CLL Lymphocytes Between and Within Patients.- p53 Mutations in B-Cell ChronicLymphocytic Leukemia.- Burkitts Lymphoma Cells Frequently Carry Monoallelic DJ Rearrangements.- Centrocytic Lymphoma: a B-Cell Non-Hodgkin’s Lymphoma Characterized by Chromosome 11 BCL-1 and PRAD 1 Rearrangements.- Two Surface Antigen Targets for Immunotoxin-Mediated Elimination of Normal and Neoplastic Murine B Cells.- Generation and Differentiation Potential of Retrovirus-lmmortalized Mature Murine B Cells.- The Role of Growth Factors in Human Lymphomas.- Production of Interleukin-6 in High Grade B Lymphomas.- Lymphomas: EBV, AIDS Associated Lymphomas.- Mutational Analysis of the Transforming Function of the EBV Encoded LMP-1.- Integration of EBV in Burkitt’s Lymphoma Cells.- The Oncogenic Potential of Epstein-Barr Virus Nuclear Antigen 1 in Transgenic Mice.- AIDS Associated Non-Hodgkin’s Lymphomas Represent a Broad Spectrum of Monoclonal and Polyclonal Lymphoproliferative Processes.- Lymphomas in Mice with Retrovirus-lnduced Immunodeficiency.- Does HIV Infection of B Lymphocytes Initiate AIDS Lymphoma? Detection by PCR of Viral Sequences in Lymphoma Tissue.- Oncogenes and Transcriptional Factors.- Lymphocyte Activation and the Family of NF-?B Transcription Factor Complexes.- Transactivation of the c-myc Gene by HTLV-1 tax is Mediated by NF-?B.- Cloning and Characterization of DNA Binding Factors Which Bind Sequences Required for Proper c-myc Initiation.- Transcriptional Activities of the Myc and Max Proteins in Mammalian Cells.- c-myc Transactivates the Ornithine Decarboxylase Gene.- v-Raf/v-Myc Synergism in Abrogation of IL-3 Dependence: v-Raf Suppresses Apoptosis.- Cyclins in the Cell Cycle: An Overview.- The Localization of the Products of the c-cbl and v-cbl Oncogenes During Mitosis and Transformation.- V-rel and C-rel Modulate the Expression of BothBursal and Non-Bursal Antigens on Avian B-Cell Lymphomas.- Why Don’t Germline Mutations in RB1 Predispose to Leukemia?.- Loss of p53 Expression in Myc-induced B Lineage Tumors.