Mechanisms and Consequences of Proton Transport

Tetsuro Urushidani is an associate professor in the Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, The University of Tokyo.John G. Forte is a professor in the Department of Molecular and Cell Biology, University of California at Berkeley.George Sachs is Director of the Membrane Biology Laboratory, University of California, Los Angeles, Professor of Physiology and Medicine, UCLA, Wilshire Chair in Medicine, UCLA, and Co-Director of the Center for Ulcer Research and Education, UCLA.

• Structure and Function of H,K-ATPase — Molecular Basis for Drug Targets.- 1. The Gastric H,K-ATPase.- 2. Human Nongastric H,K-ATPase: Current View On Structure and Functional Properties.- 3. Functional Consequences of Subunit Interactions in Na,K- and H,K-ATPases.- 4. HKc? Encodes Ouabain-Insensitive H,K-ATPase in Surface Cells of Rat Distal Colon.- 5. Molecular Diversity and Regulatory Heterogeneity of H,K-ATPases in Kidney.- 6. Mutational Analysis of Gastric Proton Pump, ?- and ß-Subunits.- 7. Structure-Activity Relationships of Na,K-ATPase and H,K-ATPase.- 8. The Effect of Mutations Within a Cluster of Homologous Amino Acids Present in the M5, M6 and M8 Transmembrane Regions of the H,K-ATPase.- Helicobacter Pylori and Mucosal Protection.- 9. Host-Specific H. pylori Inhibition of H,K-ATPase ? Subunit Gene Expression.- 10. H+, K+-ATPase, the Dominant Gastric Autoantigen In Helicobacter pylori Infection.- 11. The Gastric H/K ATPase in the Pathogenesis of Autoimmune Gastritis.- 12. Duodenal Protection: Influence of Melatonin and Other Intestinal Transmitters on Duodenal Bicarbonate Secretion and Enterocyte Signaling.- 13. Role of Cytokines in Helicobacter pylori-Induced Gastric Epithelial Cell Matrix Metalloproteinase Secretion and Activation.- 14. HCI Causes Less Intracellular Acidification in Surface Epithelial Cells of Isolated Necturus Gastric Mucosa than Other Inorganic Acids.- 15. Ethanol Increases Intracellular Free Calcium, Closes Gap Junctions and Decreases Cell Volume in Primary Cultured Rabbit Gastric Epithelial Cell Monolayers.- 16. Induction of Small Intestinal Damage by Inhibition of Both NO Synthase and COX-2.- 17. Role of Protein Kinases on Acid-Induced Duodenal Bicarbonate Secretion in Rats.- 18. Acid Induces Duodenal Epithelial Acidification andHCO3-” Secretion via Activation of the Na+:HC03-” Cotransporter and CFTR in Mice.- Gene Targeting Mouse — Mechanisms of Acid Secretion and Cell Proliferation.- 19. Insights into the Cell Biology, Development and Pathology of the Gastric Mucosa Revealed in Gastric H/K ATPase and Gastrin-Deficient Mice.- 20. Genetically Engineered Animal Models: Physiological Studies with Gastrin in Transgenic Mice.- 21. Gastric Cytoprotection by Prostaglandin E2 — Relation to EP Receptor Subtypes.- 22. Gastric Mucus Accumulation is Reduced in Helicobacter pylori pylori Infected Transgenic Mice Expressing the Human a-l,3/4-Fucosyltransferase in Surface Epithelial Cells.- Signal Transduction in the Parietal Cell — Pathway to Activation.- 23. New Insights into Second Messenger Regulation of Parietal Cell Function by Novel Downstream Signaling Proteins.- 24. Functional Role of Protein Kinase B/Akt in Gastric Acid Secretion.- 25. Permeabilized Gastric Gland Models — A New Strategy for Analyzing Parietal Cell Signal Transduction.- 26. Parietal Cell Volume Regulation During Acid Secretion.- 27. Characterization, Regulation and Localization of the Gastric CI- Channel Associated with Gastric Acid Secretion.- 28. Identification of Potassium Channels Associated with H,K-ATPase in the Parietal Cell.- 29. Kir2.1 K+ Channels of the Gastric Parietal Cell.- 30. Kinetics of Activation of H+ Secretion by Secretagogues in Relation to Changes in [Ca2+]i in Isolated Gastric Glands.- 31. Measurement of Intracellular Calcium and Gastric Acid Secretion in Real Time Using Fluorescent Probes.- 32. Tissue and Cell Distribution of Parchorin, a Chloride Intracellular Channel-Related Protein.- Cytoskeleton and Membrane Trafficking — the Gastric Parietal Cell as a Model.- 33. Scanning EM Studies ofGastric Oxyntic Cells with Special Reference to the Translocation of Tubulovesicular System towards the Intracellular Canaliculus.- 34. 3-Dimensional Modeling of the Gastric Parietal Cell.- 35. Pharmacological Control of Gastric Acid Secretion via the Apical Membrane of Parietal Cells in Dogs.- 36. The Cytoskeleton as a Modulator of Gastric Secretion.- 37. Clathrin and Associated Proteins on Tubulovesicles and Apical Membranes of Parietal Cells.- 38. Rab11 Interacting Proteins as Regulators of Parietal Cell Apical Recycling: Lessons from the Master.- 39. Regulation of Acid Secretion and Mucosal Permeability by F-actin in the Bullfrog Gastric Mucosa.- 40. Fluid Dynamics of the Excretory Flows of Zymogenic and Mucinous Contents in Rat Gastric Glands Processed by High Pressure Freezing/Freeze Substitution, with Special Reference to the Secretory Dynamics of Phospholipase A2 And Phospholipase Cyl.