Mechanisms and Concepts in Toxicology

Aldridge, W. Norman

• Scope of Toxicology. Stages in the Induction of Toxicity. Kinetics and End-points. Acute and Chronic Intoxication. Delivery of Intoxicant: Decrease in Delivery to the Target. Delivery of Intoxicant: Bioactivation and Increase in Delivery to the Target. Initiating Reactions with Targets. Biological Consequences of Initiating Reactions with Targets. Exposure, Dose and Chemical Structure, Response and Activity, and Thresholds. Selective Toxicity, Animal Experimentation and In Vitro Methods. Biomonitoring. Epidemiology. Environmental and Ecotoxicology. Reflections, Research and Risk.