5thInternational Symposium on the Mechanics of Biological Systems and Materials, Volume 6 of the Proceedings of the 2015SEM Annual Conference& Exposition on Experimental and Applied Mechanics, the sixth volume of nine from the Conference, brings together contributions to this important area of research and engineering. The collection presents early findings and case studies on a wide range of areas, including: Soft Tissues MechanicsBio-Engineering and BiomechanicsNatural Materials & Bio-InspirationNovel Techniques and Experiments in BiomechanicsTissue EngineeringCells Mechanics