Michael Frame retired in 2016 as adjunct professor of mathematics at Yale University. For more than twenty years Frame taught courses on fractal geometry and calculus based on applications in biology and medicine. Amelia Urry and he are the coauthors of Fractal Worlds: Grown, Built, and Imagined.

“Clear, enthusiastic, and communicating a love of maths, this is a useful, engaging and well-written text.”—Becca Asquith, Professor of Mathematical Immunology, Imperial College London"This is a wonderful book, wise and witty. It would have taught me most of the math I needed for my career in research – if I did all the problems."—Stephen Stearns, author of The Evolution of Life Histories and Evolutionary Medicine“This well-written book covers multivariate calculus and dynamical systems within the context of the biological sciences, providing well-chosen, up-to-date biomedical examples. The Markov chain, along with its many interesting applications, is also introduced.”—Hongyu He, Professor of Mathematics, Louisiana State University