Mathematical Modelling in Motor Neuroscience: State of the Art and Translation to the Clinic. Ocular Motor Plant and Gaze Stabilization Mechanisms

Dr. Richard Leigh is an Assistant Professor of Neurology who is devoted to the diagnosis, treatment and prevention of cerebrovascular disease. He is an attending on the inpatient stroke service and an integral part of the Brain Attack Team. He also provides consultations and follow-up care for cerebrovascular disease in the outpatient setting.Dr. Richard Leigh was originally trained as a biomedical engineer at the Johns Hopkins University and subsequently went on to work at the National Institutes of Health where he developed brain imaging software. He then embarked on obtaining his medical degree from Case Western Reserve School of Medicine in his home town of Cleveland, Ohio. He completed his medical internship and neurology residency at New York Presbyterian Hospital Weill Cornell Medical Center where he received the Distinguished House Staff Award and was selected to be Chief Resident of Neurology. Returning to Johns Hopkins, he then completed a stroke fellowship and subsequently joined the faculty of the cerebrovascular division.Dr. Leigh currently sees patients at the Stroke Prevention Clinic, located in the Johns Hopkins Outpatient Center in Baltimore on Wednesday afternoons, and cares for patients in The Johns Hopkins Hospitals Brain Stefano Ramat currently works at the Dip. Ingegneria Industriale e dell'Informazione, University of Pavia. Stefano does research in Bioengineering, Motor Neuroscience, Algorithms, Artificial Neural Network and Medical Devices. Their current project is 'Functional Vestibular Testing' Aasef G. Shaikh works at University Hospitals Cleveland Medical Center in Cleveland.

• Section I - View of the field: Past present and future1. Mathematical models and human diseaseLance M. Optican and Elena Pretegiani2. Mathematical models: An extension of the clinician's mindR. John Leigh and David S. ZeeSection II - Didactic: Modeling3. Understanding the rotational vestibular ocular reflex: From differential equations to Laplace transformsStefano Ramat4. Integration of past and current visual information during eye movements in amblyopiaNicolas Deravet, Demet Yüksel, Jean-Jacques Orban de Xivry and Philippe Lefèvre5. Mathematical models for dynamic, multisensory spatial orientation perceptionTorin K. Clark, Michael C. Newman, Faisal Karmali, Charles M. Oman and Daniel M. MerfeldSection III - Didactic: Translational6. Non-commutative, nonlinear, and non-analytic aspects of the ocular motor plantJoseph L. Demer7. Clinical applications of control systems models: The neural integrators for eye movementsShirin Sadeghpour, David S. Zee and R. John LeighSection IV - Research: Plant and binocular control8. Translation and eccentric rotation in ocular motor modelingJoseph L. Demer and Robert A. Clark9. Extraocular muscles involved in convergence are innervated by an additional set of palisade endings that may differ in their excitability: A human studyKaroline Lienbacher, Kathrin Sänger, Sebastian Strassburger, Oliver Ehrt, Günther Rudolph, Miriam Barnerssoi and Anja K.E. Horn10. On the retinal correspondences across the binocular visual fieldBernhard J.M. Hess11. Motion and binocular disparity processing: Two sides of two different coinsChristian Quaia, Edmond J FitzGibbon, Lance M Optican and Bruce G Cumming12. Non-linearity in gaze holding: Experimental results and possible mechanismsGiovanni Bertolini, Fausto Romano, Nina Feddermann, Dominik Straumann, Alexander Andrea Tarnutzer and Stefano Ramat13. Is infantile esotropia subcortical in origin?Michael C. BrodskySection V - Research: Vestibular, balance, and postural control14. The influence of target distance on perceptual self-motion thresholds and the vestibulo-ocular reflex during interaural translationSusan King, Cyril Benoit and Faisal Karmali15. Spatial orientation: Model-based approach to multi-sensory mechanismsAmir Kheradmand and Jorge Otero-Millan16. Theoretical framework for "unexplained" dizziness in the elderly: The role of small vessel diseaseDiego Kaski, Heiko M. Rust, Richard Ibitoye, Qadeer Arshad, John H.J. Allum and Adolfo M. Bronstein17. The functional head impulse test: Comparing gain and percentage of correct answersMaurizio Versino, Silvia Colnaghi, Giulia Corallo, Marco Mandalà and Stefano Ramat18. Vestibular roll tilt thresholds partially mediate age-related effects on balanceSinem Balta Beylergil, Faisal Karmali, Wei Wang, Maria Carolina Bermúdez Rey and Daniel M. Merfeld19. The velocity storage time constant balances between accuracy and precisionFaisal Karmali20. Toward dynamic modeling of visual-vestibular conflict detectionIsabelle T. Garzorz and Paul R. MacNeilage21. A conceptual model of the visual control of postureAdolfo M. Bronstein22. Computational neurology of gravity perception involving semicircular canal dysfunction in unilateral vestibular lesionsStefan Glasauer, Marianne Dieterich and Thomas Brandt23. Effect of motor and sensory noise in the control of upright standingAmel Cherif, Ian Loram and Jacopo Zenzeri24. Model of optokinetic responses involving two different visual motion processing pathwaysKenichiro Miura, Aya Takemura, Masakatsu Taki and Kenji Kawano