Mathematical Modelling in Motor Neuroscience: State of the Art and Translation to the Clinic, Gaze Orienting Mechanisms and Disease

Dr. Richard Leigh is an Assistant Professor of Neurology who is devoted to the diagnosis, treatment and prevention of cerebrovascular disease. He is an attending on the inpatient stroke service and an integral part of the Brain Attack Team. He also provides consultations and follow-up care for cerebrovascular disease in the outpatient setting.Dr. Richard Leigh was originally trained as a biomedical engineer at the Johns Hopkins University and subsequently went on to work at the National Institutes of Health where he developed brain imaging software. He then embarked on obtaining his medical degree from Case Western Reserve School of Medicine in his home town of Cleveland, Ohio. He completed his medical internship and neurology residency at New York Presbyterian Hospital Weill Cornell Medical Center where he received the Distinguished House Staff Award and was selected to be Chief Resident of Neurology. Returning to Johns Hopkins, he then completed a stroke fellowship and subsequently joined the faculty of the cerebrovascular division.Dr. Leigh currently sees patients at the Stroke Prevention Clinic, located in the Johns Hopkins Outpatient Center in Baltimore on Wednesday afternoons, and cares for patients in The Johns Hopkins Hospitals Brain Stefano Ramat currently works at the Dip. Ingegneria Industriale e dell'Informazione, University of Pavia. Stefano does research in Bioengineering, Motor Neuroscience, Algorithms, Artificial Neural Network and Medical Devices. Their current project is 'Functional Vestibular Testing' Aasef G. Shaikh works at University Hospitals Cleveland Medical Center in Cleveland.

• Section I -DIDACTIC: Modeling1. Sequential Bayesian updating as a model for human perceptionStefan Glasauer2. Maps and sensorimotor transformations for eye-head gaze shifts: Role of the midbrain superior colliculusA. John van Opstal and Bahadir Kasap3. Modeling gaze position-dependent opsoclonusLance M. Optican, Janet C. Rucker, John-Ross Rizzo and Todd E. Hudson Section II - DIDACTIC: Translational4. Eye position-dependent opsoclonus in mild traumatic brain injuryJohn-Ross Rizzo, Todd H. Hudson, Alexandra J. Sequeira, Weiwei Dai, Yash Chaudhry, John Martone, David S. Zee, Lance M. Optican, Laura J. Balcer, Steven L. Galetta and Janet C. RuckerSection III - RESEARCH: Saccades5. Saccades in Parkinson’s disease: Hypometric, slow, and maladaptiveAasef G. Shaikh and Fatema F. Ghasia6. Brainstem neural circuits for fixation and generation of saccadic eye movementsYoshikazu Shinoda, Mayu Takahashi and Yuriko Sugiuchi7. Morphological and electrophysiological characteristics of the commissural system in the superior colliculi for control of eye movementsMayu Takahashi8. Potassium channels in omnipause neuronsÜmit S Mayadali, Karoline Lienbacher, Michael Mustari, Michael Strupp and Anja KE Horn9. The cerebellum improves the precision of antisaccades by a latency-duration trade-offPietro Piu, Elena Pretegiani, Francesca Rosini, Valeria Serchi, Domenica Zaino, Tommaso Chiantini and Alessandra Rufa10. Saccade variability in healthy subjects and cerebellar patientsEggert T and Straube A11. Electrical stimulation in a spiking neural network model of monkey superior colliculusA. John van Opstal and Bahadir KasapSection IV - RESEARCH: Adaptation12. A neuronal process for adaptive control of primate saccadic systemYoshiko Kojima13. A unified computational framework for visual attention dynamicsDario Zanca, Marco Gori and Alessandra Rufa14. Improving the repeatability of two-rate model parameter estimations by using autoencoder networksOzdemir MC, Eggert T and Straube ASection V - RESEARCH: Nystagmus15. Rebound nystagmus, a window into the oculomotor integratorJorge Otero-Millan, Ayse I. Colpak, Amir Kheradmand and David S. Zee16. Central positional nystagmus: Characteristics and model-based explanationsJeong-Yoon Choi and Ji-Soo Kim17. Modulation of acquired monocular pendular nystagmus in multiple sclerosis: A modeling approachIleok Jung, Sung-Hee Kim, Hyo-Jung Kim, Jeong-Yoon Choi and Ji-Soo Kim18. Fixation instability in amblyopia: Oculomotor disease biomarkers predictive of treatment effectivenessM. Scaramuzzi, J. Murray, J. Otero-Millan, Paolo Nucci, A.G. Shaikh and F.F. GhasiaSection VI - RESEARCH: Dystonia19. What can kinematic studies tell us about the mechanisms of dystonia?Anna Sadnicka, Joseph Galea and Mark J. Edwards20. Implications of asymmetric neural activity patterns in the basal ganglia outflow in the integrative neural network model for cervical dystoniaAlexey Sedov, Ulia Semenova, Svetlana Usova, Alexey Tomskiy, J. Douglas Crawford, H.A. Jinnah and Aasef G. Shaikh21. A motor control model of task-specific dystonia and its rehabilitationAnna Sadnicka and Jaume Rosset-Llobet22. Tremor in chronic inflammatory demyelinating polyneuropathy: Proof of unifying network model for dystoniaNataliya Pyatka, Alexey Sedov, Benjamin L. Walter, H.A. Jinnah and Aasef G. ShaikhSection VII - RESEARCH: Parkinson's disease23. Oculomotor effects of medical and surgical treatments of Parkinson’s diseaseSalil Patel, James J. Fitzgerald and Chrystalina A. Antoniades24. Vestibular heading perception in Parkinson's diseaseSinem Balta Beylergil, Sarah Ozinga, Mark F. Walker, Cameron McIntyre and Aasef G. Shaikh25. A new approach for estimation of spiketrain patterns in basal gangliaVladislav Myrov, Alexey Sedov, Alexey Tomskiy, Ludmila Myrova and Elena BelovaSection VIII - RESEARCH: Others26. A model-based study of internuclear ophthalmoparesis and ocular-motor fatigue in multiple sclerosisJonathan B. Jacobs, Clara Chisari, Margaret M. Skelly, Mark F. Walker and Alessandro Serra27. Central positional vertigo: A clinical-imaging studyEmiliano De Schutter, Zachariah O. Adham and Jorge C. Kattah28. Eye-hand re-coordination: A pilot investigation of gaze and reach biofeedback in chronic strokeJohn-Ross Rizzo, Mahya Beheshti, Azadeh Shafieesabet, James Fung, Maryam Hosseini, Janet C. Rucker, Lawrence H. Snyder and Todd E. Hudson29. Kinematics and the neurophysiological study of visually-guided eye movementsLaurent Goffart30. Deficient head motor control in functional dizziness: Experimental evidence of central sensory-motor dysfunction in persistent physical symptomsNadine Lehnen, Lena Schröder, Peter Henningsen, Stefan Glasauer and Cecilia Ramaioli