This book constitutes selected and revised papers from the 22nd International Conference on Mathematical Modeling and Supercomputer Technologies, MMST 2022, held in Nizhny Novgorod, Russia, in November 2022. The 20 full papers and 5 short papers presented in the volume were thoroughly reviewed and selected from the 48 submissions. They are organized in topical secions on ​computational methods for mathematical models analysis; computation in optimization and optimal control; supercomputer simulation.