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Chapters guide readers through genetic interactions in model organisms, RNA interference, CRISPR/Cas9 based genome editing technologies, drug-gene interactions, mapping chemical genetic interactions, synergistic drug-gene relations, single cell sequencing, gene expression profiling, and novel genetic interactions.
Quantitative Genetic Screens for Mapping Bacterial Pathways and Functional Networks.- Mapping Synthetic Dosage Lethal Genetic Interactions in Saccharomyces cerevisiae.- Systematic High-Content Screening of Fluorescently-Tagged Yeast Double Mutant Strains.- A Genetic Interaction Screening Approach in C. elegans.- RNA Interference (RNAi) Screening in Cultured Drosophila Cells.- Employing Cross-Species Approaches to Construct Humanized Genetic Interaction Networks.- Identification of Synthetic Lethal Interactions Using High-Throughput, Arrayed CRISPR/Cas9-based Platforms.- Exploring Candidate Human Synthetic Lethal Interactions Through siRNA and Quantitative Imaging-Based Approaches.- Mapping Genetic Interactions in Human Cancer Cells Using a One-Step tRNA-CRISPR System.- In vivo Genome-Wide Pooled RNAi Screens in Cancer Cells to Identify Determinants of Chemotherapy/Drug Response.- INCISOR: An Algorithm to Identify Synthetic Rescue Mediators of Resistance to Targeted and Immunotherapy.- Machine Learning to Identify Gene Interactions from High-Throughput Mutant Crosses.- Identification of Drug Resistance Genes Using a Pooled Lentiviral CRISPR/Cas9 Screening Approach.- Chemical Genetic Interactions as a Means to Characterize Drug Synergy.- Puromycin Labeling Coupled with Proximity Ligation Assays to Define Sites of mRNA Translation in Drosophila Embryos and Human Cells.- Inferring Copy Number from Triple Negative Breast Cancer Patient Derived Xenograft scRNAseq Data using scCNAutils.- Generation of Protein Inhibitors for Validation of Cancer Drug Targets Identified in Functional Genomic Screens.- Computational Prediction of Chemical Tools for Identification and Validation of Synthetic Lethal Interaction Networks.
