Manual of Antisense Methodology

Häftad, Engelska, 2012

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In the past few years, antisense methodology has moved from in vitro studies to in vivo studies and first human trials. The work is organized into three sections: antisense application in vitro, antisense application in vivo (animal models) and finally, clinical antisense studies.

Produktinformation

Utgivningsdatum2012-10-12
Mått155 x 235 x 13 mm
Vikt347 g
FormatHäftad
SpråkEngelska
SeriePerspectives in Antisense Science
Antal sidor205
FörlagSpringer-Verlag New York Inc.
ISBN9781461373049

Tillhör följande kategorier

I: The chemistry of antisense oligonucleotides.- 1. Chemical synthesis and purification of phosphorothioate antisense oligonucleotides.- 2. How to choose optimal antisense targets in an mRNA.- II: Antisense application in vitro.- 3. How to characterize and improve oligonucleotide uptake into leukocytes.- 4. Strategies for targeted uptake of antisense oligonucleotides in hepatocytes.- 5. How to exclude immunostimmulatory and other nonantisense effects of antisense oligonucleotides.- 6. Testing antisense oligonucleotides in controlled cell culture assays.- 7. Inhibition of TNF synthesis by antisense oligonucleotides.- 8. Inhibition of IGF-1 receptor expression by antisense oligonucleotides in vitro and in vivo.- III: Antisense application in vivo.- 9. How to test antisense oligonucleotides in animals.- 10. Lipid-based carriers for the systemic delivery of antisense drugs.- 11. Designing a clinical antisense study.