Eric A. Klein, MD Cleveland Clinic, Glickman Urological and Kidney Institute, Cleveland, OH, USA J. Stephen Jones, MD Cleveland Clinic, Glickman Urological and Kidney Institute, Cleveland, OH, USA

• Epidemiology and Risk Factors.- Twenty years and counting: is PSA still useful in 2010?.- Prostate Cancer Screening: A Review of the Evidence with Clinical Practice Implications.- Beyond PSA: Promising New Markers for Prostate Cancer.- Hereditary Prostate Cancer and Genetic Risk.- Prostate Inflammation and Prostate Cancer.- Molecular Progression of Prostate Cancer: Androgens and Estrogens.- The Role of Obesity and Diet in Prostate Cancer.- Prostate Cancer Risk Reduction by Chemoprevention.- Current Issues in Pathologic Evaluation.- Optimum Prostate Biopsy: Technique and Strategies.- The Utility of Nomograms in Routine Clinical Practice.- Active Surveillance Comes of Age.- Focal Therapy: Prostate Hemiablation as the First Historical Treatment Model for Focal Therapy of Early Stage Prostate Cancer.- Contemporary External Beam Radiotherapy.- Surgery, Brachytherapy, or  External Beam Radiation for Low and Intermediate-Risk Disease?.- The Role for Radical Prostatectomy in Advanced Prostate Cancer.- Radiation Therapy in the Management of Locally Advanced Prostate Cancer.- Clinical Implications of Measuring Quality-of-Life in Early Stage Prostate Cancer.- Treatment Modalities of Post-Prostatectomy Incontinence: A Historical Perspective As Well As Current  Therapy Options.- Management of Biochemical Recurrence After Localized Treatment for Prostate Cancer.- Management of Newly Diagnosed Metastatic Disease.- Pitfalls of Androgen Deprivation Therapy.- Current Management of Castration-resistant Prostate Cancer (CRPC).- Radiopharmaceuticals and Bone Metastasis.

From the reviews of the third edition: "Klein and Jones, with the support of 50 experts, wrote an updated and expanded third version of their excellent textbook. ... A substantial part of the book dealt with the treatments of localised, locally advanced and metastatic disease. ... This textbook presents an inclusive coverage of practical information and can be recommended for all urologists and oncologists, either certified or still in training." (European Urology Today, Vol. 25 (2), March-May, 2013) "This update on the management of prostate cancer is a must read not only for every urologist, but also for any clinician who wants a better understanding of this disease. ... This book is definitely needed in an area where there have been such rapid changes. Although the book is targeted at medical students, residents, practitioners in urology other specialties, even lay people can appreciate some of the chapters. They are written very clearly, with easily understandable graphs and illustrations." (Jack Mydlo, Doody's Book Reviews, 2012)

Eric A. Klein, MD Cleveland Clinic, Glickman Urological and Kidney Institute, Cleveland, OH, USA J. Stephen Jones, MD Cleveland Clinic, Glickman Urological and Kidney Institute, Cleveland, OH, USA

• Epidemiology and Risk Factors.- Twenty years and counting: is PSA still useful in 2010?.- Prostate Cancer Screening: A Review of the Evidence with Clinical Practice Implications.- Beyond PSA: Promising New Markers for Prostate Cancer.- Hereditary Prostate Cancer and Genetic Risk.- Prostate Inflammation and Prostate Cancer.- Molecular Progression of Prostate Cancer: Androgens and Estrogens.- The Role of Obesity and Diet in Prostate Cancer.- Prostate Cancer Risk Reduction by Chemoprevention.- Current Issues in Pathologic Evaluation.- Optimum Prostate Biopsy: Technique and Strategies.- The Utility of Nomograms in Routine Clinical Practice.- Active Surveillance Comes of Age.- Focal Therapy: Prostate Hemiablation as the First Historical Treatment Model for Focal Therapy of Early Stage Prostate Cancer.- Contemporary External Beam Radiotherapy.- Surgery, Brachytherapy, or  External Beam Radiation for Low and Intermediate-Risk Disease?.- The Role for Radical Prostatectomy in Advanced Prostate Cancer.- Radiation Therapy in the Management of Locally Advanced Prostate Cancer.- Clinical Implications of Measuring Quality-of-Life in Early Stage Prostate Cancer.- Treatment Modalities of Post-Prostatectomy Incontinence: A Historical Perspective As Well As Current  Therapy Options.- Management of Biochemical Recurrence After Localized Treatment for Prostate Cancer.- Management of Newly Diagnosed Metastatic Disease.- Pitfalls of Androgen Deprivation Therapy.- Current Management of Castration-resistant Prostate Cancer (CRPC).- Radiopharmaceuticals and Bone Metastasis.

From the reviews of the third edition: "Klein and Jones, with the support of 50 experts, wrote an updated and expanded third version of their excellent textbook. ... A substantial part of the book dealt with the treatments of localised, locally advanced and metastatic disease. ... This textbook presents an inclusive coverage of practical information and can be recommended for all urologists and oncologists, either certified or still in training." (European Urology Today, Vol. 25 (2), March-May, 2013) "This update on the management of prostate cancer is a must read not only for every urologist, but also for any clinician who wants a better understanding of this disease. ... This book is definitely needed in an area where there have been such rapid changes. Although the book is targeted at medical students, residents, practitioners in urology other specialties, even lay people can appreciate some of the chapters. They are written very clearly, with easily understandable graphs and illustrations." (Jack Mydlo, Doody's Book Reviews, 2012)

Eric A. Klein, MD Cleveland Clinic, Glickman Urological and Kidney Institute, Cleveland, OH, USA J. Stephen Jones, MD Cleveland Clinic, Glickman Urological and Kidney Institute, Cleveland, OH, USA

• Epidemiology and Risk Factors.- Twenty years and counting: is PSA still useful in 2010?.- Prostate Cancer Screening: A Review of the Evidence with Clinical Practice Implications.- Beyond PSA: Promising New Markers for Prostate Cancer.- Hereditary Prostate Cancer and Genetic Risk.- Prostate Inflammation and Prostate Cancer.- Molecular Progression of Prostate Cancer: Androgens and Estrogens.- The Role of Obesity and Diet in Prostate Cancer.- Prostate Cancer Risk Reduction by Chemoprevention.- Current Issues in Pathologic Evaluation.- Optimum Prostate Biopsy: Technique and Strategies.- The Utility of Nomograms in Routine Clinical Practice.- Active Surveillance Comes of Age.- Focal Therapy: Prostate Hemiablation as the First Historical Treatment Model for Focal Therapy of Early Stage Prostate Cancer.- Contemporary External Beam Radiotherapy.- Surgery, Brachytherapy, or  External Beam Radiation for Low and Intermediate-Risk Disease?.- The Role for Radical Prostatectomy in Advanced Prostate Cancer.- Radiation Therapy in the Management of Locally Advanced Prostate Cancer.- Clinical Implications of Measuring Quality-of-Life in Early Stage Prostate Cancer.- Treatment Modalities of Post-Prostatectomy Incontinence: A Historical Perspective As Well As Current  Therapy Options.- Management of Biochemical Recurrence After Localized Treatment for Prostate Cancer.- Management of Newly Diagnosed Metastatic Disease.- Pitfalls of Androgen Deprivation Therapy.- Current Management of Castration-resistant Prostate Cancer (CRPC).- Radiopharmaceuticals and Bone Metastasis.

From the reviews of the third edition: "Klein and Jones, with the support of 50 experts, wrote an updated and expanded third version of their excellent textbook. ... A substantial part of the book dealt with the treatments of localised, locally advanced and metastatic disease. ... This textbook presents an inclusive coverage of practical information and can be recommended for all urologists and oncologists, either certified or still in training." (European Urology Today, Vol. 25 (2), March-May, 2013) "This update on the management of prostate cancer is a must read not only for every urologist, but also for any clinician who wants a better understanding of this disease. ... This book is definitely needed in an area where there have been such rapid changes. Although the book is targeted at medical students, residents, practitioners in urology other specialties, even lay people can appreciate some of the chapters. They are written very clearly, with easily understandable graphs and illustrations." (Jack Mydlo, Doody's Book Reviews, 2012)