Malignant Mesothelioma

Pathogenesis, Diagnosis, and Translational Therapies

Inbunden, Engelska, 2005

AvHarvey I. Pass,Nicholas Vogelzang,Michele Carbone

2 849 kr

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Malignant mesothelioma is a rare form of cancer, in which the cancer cells are found in the sac lining the chest (pleura) or abdomen (peritoneum). This lethal disease is associated with asbestos and has vast economic and legal implications. As the disease takes approximately twenty years to manifest itself in humans, a wave of diagnoses is expected in the near future. In the United States alone, an estimated 3,500 - 4,000 patients are diagnosed with mesothelioma annually, and it is estimated that over the next 35 years, more than 250,000 people in Western Europe will be diagnosed with the disease. Malignant Mesothelioma, edited by internationally recognized experts in the field, is a comprehensive text that relates science, pathology, clinical aspects and therapy for mesothelioma under one cover. The book integrates the newest research and advances in its discussions of the disease, covering such topics as carcinogenesis, epidemiology, benchwork, endoscopy, multimodality approaches and treatment.It includes discussions on novel approaches to mesothelioma, such as gene therapy, vaccination strategies and immunotherapy, as well as discussions on the legal and economic aspects of the disease. Over 200 illustrations round out the text. An invaluable reference for the medical oncologist, thoracic surgeon, radiation oncologist, pulmonologist, and benchworker interested in the disease.

Produktinformation

Utgivningsdatum2005-06-14
Mått178 x 254 x 42 mm
Vikt1 870 g
FormatInbunden
SpråkEngelska
Antal sidor854
FörlagSpringer-Verlag New York Inc.
ISBN9780387229492

Tillhör följande kategorier

Onkologi inom Medicin
Thoraxkirurgi och hjärtkirurgi inom Medicin

Carcinogenesis.- The History of Mesothelioma.- Asbestos-Induced Mesothelioma.- SV40-Mediated Oncogenesis.- Mesothelioma Carcinogenesis: In Vivo Models.- Mesothelial and Mesothelioma Cell Lines.- Molecular Genetics.- Cytogenetics of Malignant Mesothelioma.- Growth Factors and Malignant Mesothelioma.- Oncogenes and Tumor Suppressor Genes in Malignant Mesothelioma.- Angiogenesis and Mesothelioma.- Immune Status and Mesothelioma.- Extracellular Matrix and Mesothelioma: Some Clues to the Invasive Behavior of Mesothelioma.- Genomics and Proteomics in Mesothelioma.- Epidemiology.- Asbestos Mineralogy and Health Effects.- Molecular Epidemiology of Mesothelioma.- Malignant Mesothelioma and Erionite.- Determination of Asbestos Exposure by Pathology and Clinical History.- Mesothelioma and Asbestos Exposure.- From Monkey to Man: The Epidemiologic Evidence of an Association Between Simian Virus 40 and Malignancy.- Causes and Prevention of Technical Artifacts When Studying Simian Virus 40 (SV40) in Human Mesotheliomas.- Molecular Detection of Siman Virus 40 in Human Mesothelioma.- Malignant Mesothelioma Following Radiation.- Genetics and Human Mesothelioma.- Clinical Presentation.- Clinicians’ Approach to Mesothelioma.- Clinical Presentation and Natural History of Mesothelioma: Pleural and Pericardial.- Clinical Presentation and Natural History of Mesothelioma: Abdominal.- Staging of Mesothelioma.- Prognostic Factors in Mesothelioma.- Imaging and Endoscopy.- Radiologic Assessment of Mesothelioma.- Endoscopic Imaging.- Pathology.- Benign Mesotheliomas, Mesothelial Proliferations, and Their Possible Association with Asbestos Exposure.- Cytology of Malignant Mesothelioma.- Immunohistochemistry.- Malignant Mesothelioma Electron Microscopy.- Rare Variants of Mesothelioma.-Differentiating Sarcomas from Mesotheliomas.- Diagnosis of Synovial Sarcoma of the Pleura and Differentiation from Malignant Mesothelioma.- Pitfalls in the Diagnosis of Malignant Mesothelioma.- Treatment.- Management of Benign Variants of Mesothelioma.- First-Line Chemotherapy for Malignant Pleural Mesothelioma.- Second-Line Chemotherapy.- Treatment of Mesothelioma with Radiotherapy.- Multimodality Approaches.- Intrapleural Chemotherapy with and Without Surgery in Malignant Pleural Mesothelioma (MPM).- Management of Pleural Effusions in Mesothelioma.- Preoperative Chemotherapy and Surgery.- Photodynamic Therapy for Pleural Mesothelioma.- Surgery and Postoperative Radiotherapy.- The Development of the Brigham and Women’s Multimodality Treatment Plan for Malignant Pleural Mesothelioma: A Model for Improving the Treatment of Rare Diseases.- Peritoneal Mesothelioma: The Columbia Experience.- Surgery, Hyperthermic Chemoperfusion, and Postoperative Chemotherapy: The National Cancer Institute and Washington Hospital Center Experience.- Pericardial and Tunica Vaginalis Mesothelioma.- Novel Treatment Strategies.- New Target Therapies for Malignant Mesothelioma.- Gene Therapy for Malignant Pleural Mesothelioma.- Immunotherapeutic Approaches and Vaccination Strategies.- Economic Implications.- Economic Aspects of Mesothelioma.

From the reviews: "Malignant Mesothelioma is an uncommon neoplasm usually associated with exposure to asbestos. ... Harvey Pass and colleagues have edited an up-to-date, comprehensive book that includes a wide range of information, from a historical perspective to descriptions of the latest treatment. ... Laboratory researchers will use it as a resource for information ... of mesothelioma. ... Clinicians will benefit from this complete guide ... . I highly recommend this book to all those who are interested in mesothelioma." (Julie R. Brahmer, The New England Journal of Medicine, March, 2006) "This is a reference book suitable for departmental and medical libraries and for the shelves of those who have a particular clinical or research interest in mesothelioma ... . Pass, Vogelzang and Carbone envisioned a comprehensive text and have achieved it. ... To be useful such a book must be well indexed; and this is. The individual chapters are well referenced ... . The text is well edited ... . This is a quality production. ... Overall it is highly recommended." (Michael Byrne, CancerForum, Vol. 30 (3), November, 2006)