Malignant Liver Tumors

Editor-in-Chief:Pierre-Alain ClavienDepartment of Visceral and Transplant Surgery, University Hospital Zurich, SwitzerlandAssociate Editors:Tadatoshi Takayama, Second Department of Surgery, Faculty of Medicine, University of Tokyo, Japan CM Lo, Liver Transplant Centre, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong R. Chari, Associate Professor of Surgery and Cancer Biology, Division Chief of Hepatobillary Surgery and Liver Transplantation, Staff Surgeon, Veterans Affairs Medical Center, Vanderbilt University Medical Center, Nashville, USA M. Morse, Associate Professor, Duke University Medical School, Durham, USA J. Llovet, Barcelona-Clínic Liver Cancer Group, Liver Unit, Institut d'Investigacions Biomédiques August Pi I Sunyer, Hospital Clínic, University of Barcelona, Catalonia, Spain

• Contributors, vii Preface, xiAcknowledgments, xiiiAbbreviations, xivSection 1 Introduction, 11 From Promethean to Modern Times, 3Kuno Lehmann, Stefan Breitenstein, and Pierre-Alain Clavien2 Hepatic Anatomy and Terminology, 11Steven M. StrasbergSection 2 Epidemiology and Diagnosis, 27Introduction, 29Chung-Mau Lo3 Histology and Pathology of Normal and Diseased Liver, 30Valérie Paradis and Achim Weber4 Pathology of Primary and Secondary Malignant Liver Tumors, 40Kay Washington5 Epidemiology, Etiology, and Natural History of Hepatocellular Carcinoma, 52Wei-Chen Lee and Miin-Fu Chen6 Epidemiology, Etiology, and Natural History of Cholangiocarcinoma, 56Peter Neuhaus, Ulf P. Neumann, and Daniel Seehofer7 Epidemiology, Etiology, and Natural History of Colorectal Liver Metastases, 64Robert J. Porte8 Tumor Markers in Primary and Secondary Liver Tumors, 69Ketsia B. Pierre and Ravi S. Chari9 Modalities for Imaging Liver Tumors, 76Dominik Weishaupt and Thomas F. HanySection 3 Systemic and Regional Therapies, 103Introduction, 105Ravi S. Chari10 Systemic Treatment of Hepatobiliary Tumors, 107Panagiotis Samaras, Michael A. Morse, and Bernhard C. Pestalozzi11 External Beam Radiation Therapy for Liver Tumors, 122Rakesh Reddy and A. Bapsi Chakravarthy12 Internal Radiation Therapy for Liver Tumors, 131Ahsun Riaz, Laura Kulik, Michael Abecassis, and Riad Salem13 Transarterial Embolization for Patients with Hepatocellular Carcinoma, 139Jordi Bruix, Carmen Ayuso, and Maria I. Real14 Selective Continuous Intra-arterial Chemotherapy for Liver Tumors, 151Fidel D. Huitzil-Melendez, Stefan Breitenstein, and Nancy Kemeny15 Isolated Hepatic Perfusion and Percutaneous Hepatic Perfusion, 164Charles K. Heller, III, James F. Pingpank, and Steven K. LibuttiSection 4 Resection, Ablation or Transplantation for Liver Tumors, 173Introduction, 175Jean-Nicolas Vauthey and Tadatoshi Takayama16 Liver Resection of Primary Tumors: Hepatocellular Carcinoma, Cholangiocarcinoma, and Gallbladder Cancer, 177Tadatoshi Takayama and Masatoshi Makuuchi17 Liver Resection of Colorectal Liver Metastases, 192Daria Zorzi, Yun Shin Chun, and Jean-Nicolas Vauthey18 Laparoscopic Liver Resection, 203Luca Viganò and Daniel Cherqui19 Repeat Resection for Liver Tumors, 216Mickael Lesurtel and Henrik Petrowsky20 Cryoablation of Liver Tumors, 227Sivakumar Gananadha and David L. Morris21 Thermal Ablation of Liver Tumors by Radiofrequency, Microwave, and Laser Therapy, 244M. B. Majella Doyle and David C. Linehan22 Ethanol and Other Percutaneous Injection Modalities in the Treatment of Liver Tumors, 266Michael A. Heneghan and Andrew D. Yeoman23 Transplantation for Liver Tumors, 281François Durand, Claire Francoz, and Jacques Belghiti24 Preventing Recurrence of Hepatocellular Carcinoma after Curative Resection, 296Stefan Breitenstein, Dimitris Dimitroulis, and Beat MüllhauptSection 5 Guidelines for Liver Tumor Treatment, 305Introduction, 307Stefan Breitenstein and Pierre-Alain Clavien25 Strategies for Safer Liver Surgery, 308Philipp Dutkowski, Olivier de Rougemont, and Pierre-Alain Clavien26 Hepatocellular Carcinoma, 317Tadatoshi Takayama27 Cholangiocarcinoma, 324Jacques Belghiti and Charles B. Rosen28 Gallbladder Cancer, 333Juan Hepp and Chung-Mau Lo29 Colorectal Liver Metastases, 342Phuong L. Doan, Jean-Nicolas Vauthey, Martin Palavecino, and Michael A. MorseSection 6 Emerging Therapies, 347Introduction, 349Michael A. Morse and Josep M. Llovet30 Viral-Based Therapies for Primary and Secondary Liver Cancer, 352Menghua Dai, Lorena Gonzalez, and Yuman Fong31 Signaling Pathways and Rationale for Molecular Therapies in Hepatocellular Carcinoma, 368Augusto Villanueva, Clara Alsinet, and Josep M. Llovet32 Novel Therapies Targeted at Signal Transduction in Liver Tumors, 382Fidel D. Huitzil-Melendez, Ghassan K. Abou-Alfa, and Michael A. Morse33 Induction of Apoptosis in Liver Tumors, 393Markus Selzner and Pierre-Alain Clavien34 Antiangiogenic Agents for Liver Tumors, 400Mathijs Vogten, Emile E. Voest, and Inne H.M. Borel Rinkes35 Integrative Oncology: Alternative and Complementary Treatments, 414Barrie R. Cassileth and Jyothirmai GubiliSection 7 Special Tumors, Population, and Special Considerations, 421Introduction, 423Stefan Breitenstein and Pierre-Alain Clavien36 Liver Metastases from Endocrine Tumors, 424Clayton D. Knox and C. Wright Pinson37 Uncommon Primary and Metastatic Liver Tumors, 439Stefan Breitenstein, Ashraf Mohammad El-Badry, and Pierre-Alain Clavien38 Liver Tumors in Special Populations, 454Tadahiro Uemura, Akhtar Khan, and Zakiyah Kadry39 Malignant Liver Tumors in Children, 475Xavier Rogiers and Ruth De Bruyne40 Liver Tumors in Asia, 487Norihiro Kokudo, Sumihito Tamura, and Masatoshi Makuuchi41 Liver Tumors in South America, 500Lucas McCormack and Eduardo de Santibañes42 Liver Tumors in Africa, 509Michael C. Kew43 Anesthetic Management of Liver Surgery, 519Marco P. Zalunardo44 Qualitative and Economic Aspects of Liver Surgery, 531René Vonlanthen, Ksenija Slankamenac, and Christian ErnstIndex, 539

“This book is a worthy update. A significant amount of material has been added, including the new section. It definitely justifies replacing the old edition and will be a valuable resource for physicians of all disciplines involved in the care of these patients.”  (Doody’s, 23 March 2012)"The third edition of Malignant Liver Tumors is well written with broad coverage of primary and metastatic liver tumors with a particular emphasis on current and emerging treatment. Consisting of up-to-date and comprehensive reviews on management of hepatic neoplasms, this book will not only be instructive to liver surgeons, trainees, and fellows, but also be valuable to hepatologists, oncologists, and interventional radiologists who form the multidisciplinary team to manage patients with these tumors." (Gastroenterological, 1 March 2011)