MACPF/CDC Proteins - Agents of Defence, Attack and Invasion

Inbunden, Engelska, 2014

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This book focusses on evolutionary, structural and functional aspects of pore-forming proteins, bringing together prominent researchers in the fields of structural biology and cellular and biophysical techniques.

Produktinformation

Utgivningsdatum2014-05-19
Mått155 x 235 x 25 mm
Vikt682 g
FormatInbunden
SpråkEngelska
SerieSubcellular Biochemistry
Antal sidor329
Upplaga2014
FörlagSpringer
ISBN9789401788809

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Biokemi inom Naturvetenskap och teknik

Part I: Overview of MACPF/CDCs.- Introduction: Brief Historical Overview.- Distribution of MACPF/CDC proteins.- Evolution of the Complement System.- Part II: Structures of MACPF/CDCs.- Structural Features of Cholesterol Dependent Cytolysins and Comparison to other MACPF-domain containing proteins.- Perfringolysin O Structure and Mechanism of Pore Formation as a Paradigm for Cholesterol-Dependent Cytolysins.- Structural Biology of the Membrane Attack Complex.- Part III: Functional aspect.- Membrane Interactions and Cellular Effects of MACPF/CDC Proteins.- The Biology of Pneumolysin.- Multifaceted Activity of Listeriolysin O, the Cholesterol-Dependent Cytolysin of Listeria monocytogenes.- Perforin - a Key Pore-Forming Protein for Immune Control of Viruses and Cancer.- Perforin and Human Diseases.- The role of MACPF Proteins in the Biology of Malaria and other Apicomplexan Parasites.- Chlamydial MACPF Protein CT153.- Fungal MACPF-Like Proteins and Aegerolysins: Bi-Component Pore-Forming Proteins?.- Fluorescence Imaging of MACPF/CDC Proteins: New Techniques and Their Application.