M2 Macrophage

Tamás Röszer is a Research Group Leader and Lecturer (Privatdozent) at the Institute of Neurobiology, Ulm University, Germany. His chief research interests are the endocrine control of immunity and metabolism, and macrophage biology in the context of development and physiology. He is the author of several research articles in the field of immunometabolism, diabetes and comparative molecular endocrinology, and reference books in nitric oxide biology and pathophysiology.

• Chapter 1. Introduction. What is an M2 macrophage? Historical overview of the macrophage polarization model. The Th1/Th2 and M1/M2 paradigms, the arginine fork.- Chapter 2. Evolutionary origin of the M2 macrophage activation: invertebrates.- Chapter 3. Evolution of M2 macrophage functions in chordates.- Chapter 4. Signal mechanisms of M2 macrophage activation.- Chapter 5. Mechanisms which control the size of M2 macrophage-dominated tissue macrophage niches.- Chapter 6.Immune functions of the M2 macrophages: host defense, self-tolerance and autoimmunity.- Chapter 7. M2 macrophages in the integument and in the musculoskeletal system.- Chapter 8. M2 macrophages in the circulatory-, respiratory and excretory organs.- Chapter 9. M2 macrophages in the metabolic organs and in the neuroendocrine system.- Chapter 10. Practical approaches in M2 macrophage biology: analysis, pharmacology and didactical interpretation of M2 macrophage functions.