Long Circulating Liposomes: Old Drugs, New Therapeutics

Häftad, Engelska, 2013

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This book provides an up-to-date evaluation of clinical aspects of newly available "long-circulating liposome" formulations. Based on results from numerous clinical studies, the book describes the fundamentals of this new technology, discusses how it may influence the pharmacology of existing well-known agents reformulated in this manner, and elaborates on future expectations. It provides the practicing clinician - in particular, oncologists and critical care infectious disease physicians - with the tools needed to use these new formulations towards the best outcome for the patient.

Produktinformation

Utgivningsdatum2013-11-13
Mått155 x 235 x 18 mm
Vikt493 g
FormatHäftad
SpråkEngelska
SerieBiotechnology Intelligence Unit
Antal sidor301
FörlagSpringer-Verlag Berlin and Heidelberg GmbH & Co. KG
ISBN9783662221174

Tillhör följande kategorier

Onkologi inom Medicin
Biokemisk teknik inom Naturvetenskap och teknik
Medicinsk utrustning och medicinska tekniker inom Medicin
Cellbiologi inom Naturvetenskap och teknik
Farmakologi inom Medicin

1. Long Circulating Liposome Therapeutics: From Concept to Clinical Reality.- 2. Oncologic Agents in Sterically Stabilized Liposomes: Basic Considerations.- 3. Liposomal Vincristine: The Central Role of Drug Retention in Defining Therapeutically Optimized Anticancer Formulations.- 4. Long Circulating Liposome-Encapsulated Tumor Necrosis Factor in the Treatment of Solid Tumors.- 5. Therapy of Human Carcinoma Xenografts with Doxorubicin Encapsulated in Sterically Stabilized Liposomes (DOXIL®): Efficacy and Safety Studies.- 6. Design and Development of Long Circulating Liposomal Daunorubicin for In Vivo Targeting of Solid Tumors: DaunoXome®.- 7. Enhancement of Doxorubicin by Encapsulation in Long circulating Thermosensitive Liposomes Combined with Local Hyperthermia.- 8. Liposomal Localization and Chemotherapy for AIDS-Related Kaposi’s Sarcoma.- 9. Pegylated-Liposomal Doxorubicin (Doxil®) in the Treatment of AIDS-Related Kaposi’s Sarcoma.- 10. DaunoXome® (Liposomal Daunorubicin) for First-Line Treatment of Advanced, HIV-Related Kaposi’s Sarcoma.- 11. Initial Clinical Evaluation of Pegylated-Liposomal Doxorubicin in Solid Tumors.- 12. Antibacterial Therapy with Sterically Stabilized Liposome Formulations.- 13. AmBisome®: Long Circulating Liposomal Formulation of Amphotericin B.- 14. Steric Stabilization of Liposomes Containing Amphotericin B: A Future Direction in Antifungal Therapy?.- 15. Clinical and Preclinical Studies with Low-Clearance Liposomal Amikacin (MiKasome®).- 16. Sterically Stabilized Liposomes to Image Infection and Inflammation.- 17. Long Circulating Liposomes for Diagnostic Imaging.- 18. Tumor Imaging with Long Circulating Liposomes.- 19. Antibody-Mediated Targeting of PEG-Coated Liposomes.- 20. Small Molecule Ligands for Targeting LongCirculating Liposomes.