Logical Modeling of Biological Systems

Inbunden, Engelska, 2014

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Systems Biology is the systematic study of the interactions between the components of a biological system and studies how these interactions give rise to the function and behavior of the living system. Through this, a life process is to be understood as a whole system rather than the collection of the parts considered separately. Systems Biology is therefore more than just an emerging field: it represents a new way of thinking about biology with a dramatic impact on the way that research is performed. The logical approach provides an intuitive method to provide explanations based on an expressive relational language.This book covers various aspects of logical modeling of biological systems, bringing together 10 recent logic-based approaches to Systems Biology by leading scientists. The chapters cover the biological fields of gene regulatory networks, signaling networks, metabolic pathways, molecular interaction and network dynamics, and show logical methods for these domains based on propositional and first-order logic, logic programming, answer set programming, temporal logic, Boolean networks, Petri nets, process hitting, and abductive and inductive logic programming.It provides an excellent guide for all scientists, biologists, bioinformaticians, and engineers, who are interested in logic-based modeling of biological systems, and the authors hope that new scientists will be encouraged to join this exciting scientific endeavor.

Produktinformation

Utgivningsdatum2014-07-29
Mått163 x 241 x 31 mm
Vikt780 g
FormatInbunden
SpråkEngelska
Antal sidor410
FörlagISTE Ltd and John Wiley & Sons Inc
ISBN9781848216808

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Biokemisk teknik inom Naturvetenskap och teknik

Foreword xiiiLuis Fariñas Del Cerro Chapter 1 Symbolic Representation and Inference or Regulatory Network Structures 1Nataly Maimari, Krysia Broda, Antonis Kakas, Rob Krams and Alessandra RussoChapter 2 Reasoning on the Response of Logical Signaling Networks with ASP 49Torsten Schaub, Anne Siegek and Santiago VidelaChapter 3 A Logical Model for Molecular Interaction Maps 93Robert DeMolombe, Luis Farinas Del Cerro and Naji ObeidChapter 4 Analyzing Large Network Dynamics with Process Hitting 125Loic Paulevé, Courtney Chancellor, Maxime Folschette, Morgan Magnin and Olivier RouxChapter 5 ASP for Construction and Validation of Regulatory Biological NetworksAlexandre Rocca, Nicolas Mobilia, Éric Fanchon, Tony Ribeiro, Laurent Trilling and Katsumi InoueChapter 6 Simulation-Based Reasoning about Biological Pathways Using Petri Nets and ASP 207Saadat Anwar, Chitta Barbal and Katsumi InoueChapter 7 Formal Methods Applied to Gene Networks Modeling 245Gilles Bernot, Jean-Paul Comet and El Houssine SnaussiChapter 8 Temporal Logic Modeling of Dynamical Behaviors: First-Order Patterns and Solvers 291François Fages and Pauline TraynardChapter 9 Analyzing SBGN-AF Networks Using Normal Logic Programs 325Adrien Rougny, Christine Froidevaux, Yoshitaka Yamamoto and Katsumi InoueChapter 10 Machine Learning of Biological Networks Using Abductive ILP 363Alireza Tamassoni, Diahuan Lin, Hiroaki Watanabe, Jianzhong Chen and Stephen MuggletonList of Authors 403Index 407