Jean-Paul Behr is the editor of The Lock-and-Key Principle: The State of the Art--100 Years On, published by Wiley.

• Contributors viiPreface ix1 Emil Fischer’s Lock-and-Key Hypothesis after 100 Years—Towards a Supracellular Chemistry 1Friedrich Cramer2 Molecular Recognition in Biology: Models for Analysis of Protein-Ligand Interactions 25Doron Lancet, Amnon Horovitz and Ephraim Katchalski-Katzir3 New Biocatalysts via Chemical Modification 73Ian M. Bell and Donald Hilvert4 Oligonucleotides: Superspecific Ligands for Targeting Nucleic Acids and Proteins and Development of Molecular Devices 89V. V. Vlassov5 Macrocycles and Antibodies as Catalysts 149D. B. Smithrud and S. J. Benkovic6 Lock-and-Key Processes at Crystalline Interfaces: Relevance to the Spontaneous Generation of Chirality 173Isabelle Weissbuch, Ronit Popovitz-Biro, Leslie Leiscrowitz and Meir Lahav7 A Model of the Origin of Life and Perspectives in Supramolecular Engineering 247H. Kuhn and J. Waser8 Perspectives in Supramolecular Chemistry—From the Lock-and-Key Image to the Information Paradigm 307Jean-Marie LehnIndex 319

Jean-Paul Behr is the editor of The Lock-and-Key Principle: The State of the Art--100 Years On, published by Wiley.

• Contributors viiPreface ix1 Emil Fischer’s Lock-and-Key Hypothesis after 100 Years—Towards a Supracellular Chemistry 1Friedrich Cramer2 Molecular Recognition in Biology: Models for Analysis of Protein-Ligand Interactions 25Doron Lancet, Amnon Horovitz and Ephraim Katchalski-Katzir3 New Biocatalysts via Chemical Modification 73Ian M. Bell and Donald Hilvert4 Oligonucleotides: Superspecific Ligands for Targeting Nucleic Acids and Proteins and Development of Molecular Devices 89V. V. Vlassov5 Macrocycles and Antibodies as Catalysts 149D. B. Smithrud and S. J. Benkovic6 Lock-and-Key Processes at Crystalline Interfaces: Relevance to the Spontaneous Generation of Chirality 173Isabelle Weissbuch, Ronit Popovitz-Biro, Leslie Leiscrowitz and Meir Lahav7 A Model of the Origin of Life and Perspectives in Supramolecular Engineering 247H. Kuhn and J. Waser8 Perspectives in Supramolecular Chemistry—From the Lock-and-Key Image to the Information Paradigm 307Jean-Marie LehnIndex 319

Jean-Paul Behr is the editor of The Lock-and-Key Principle: The State of the Art--100 Years On, published by Wiley.

• Contributors viiPreface ix1 Emil Fischer’s Lock-and-Key Hypothesis after 100 Years—Towards a Supracellular Chemistry 1Friedrich Cramer2 Molecular Recognition in Biology: Models for Analysis of Protein-Ligand Interactions 25Doron Lancet, Amnon Horovitz and Ephraim Katchalski-Katzir3 New Biocatalysts via Chemical Modification 73Ian M. Bell and Donald Hilvert4 Oligonucleotides: Superspecific Ligands for Targeting Nucleic Acids and Proteins and Development of Molecular Devices 89V. V. Vlassov5 Macrocycles and Antibodies as Catalysts 149D. B. Smithrud and S. J. Benkovic6 Lock-and-Key Processes at Crystalline Interfaces: Relevance to the Spontaneous Generation of Chirality 173Isabelle Weissbuch, Ronit Popovitz-Biro, Leslie Leiscrowitz and Meir Lahav7 A Model of the Origin of Life and Perspectives in Supramolecular Engineering 247H. Kuhn and J. Waser8 Perspectives in Supramolecular Chemistry—From the Lock-and-Key Image to the Information Paradigm 307Jean-Marie LehnIndex 319