Liver Transplantation and Hepatobiliary Surgery

Luciano De Carlis is Professor of General Surgery at the University of Milano-Bicocca School of Medicine, Director of the Department of Surgery and Chief of the Abdominal Transplant Program at Niguarda Hospital, Milan, Italy. He studied in Milan and trained in Pittsburgh (USA), Essen (Germany), Tokyo and Kyoto (Japan). He has performed, as first surgeon, more than 5000 major operations in the field of General Surgery with a special focus on hepatopancreatobiliary surgery, vascular surgery and transplantation (liver, kidney and pancreas) and more than 8000 operations were performed in Niguarda Hospital under his direction. In 2001 he performed the first adult-to-adult living donor liver transplantation in Italy, and his Center is at the forefront of this field, with more than 100 cases operated on. He is a pioneer in combined organ transplantation performing the first liver and pancreas transplantation in italy in 2009.In 2015 he performed the first liver transplantation froma deceased heart donor in Italy and promoted this program despite the legal hurdle requiring 20 minutes of cardiac arrest for a declaration of death. He was Chairman and Invited Speaker in more than 300 national and international Congresses in General and transplantation Surgery. His scientific output includes over 230 papers in national and international peer-reviewed journals and books (Total Impact 873.2; H INDEX 31 -Scopus- 32 -Google Scholar-; Total Number of Citations 4709).. He is a member of the Italian Society for Organ Transplantation (SITO), European Society for Organ Transplantation (ESOT), International Society of Transplantation, and Italian Society of Surgery (SIS) and Italian Association of Hospital Surgeons (ACOI).   Umberto Cillo is Professor of General Surgery and Director of the Hepatobiliary Surgery and Liver Transplant Unit at the University of Padua, Italy. A specialist in Emergency Surgery, he was a Research Associate in Transplantation at the University of Pittsburgh-School of Medicine from 1990 to 1992 and subsequently a Researcher in Italy, where he was appointed as Associate Professor and later Full Professor of General Surgery at the University of Padua. Since 2004 he has performed as first practitioner over 550 liver transplantations including over 90 pediatric, adult-to-child, and adult-to-adult split transplants, living donor transplants, and autotransplants, as well as over 700 liver resections. Since 2011 to 2015 he coordinated the liver allocation remodeling in Italy through a process including four methodologically stringent consensus conferences and a public appraisal. He is author or co-author of 135 peer-reviewed publications. He is President of the Italian Society for Organ Transplantation (SITO), a member of the Council of European Society for Organ Transplantation (ESOT), and a member of Italian Society of Surgery.

• 1 Introduction.- 2 Cross training and didactic interplay.- 3 Preoperatory assessment of comorbidities in liver transplantation and  HBP surgery.- 4 Vascular exclusion.- 5 Cooling technique.- 6 Machine perfusions.- 7 Chirurgia Ex situ.- 8 Vascular reconstructions.- 9 Biliary reconstruction.- 10 LDLT.- 11 Pediatric LDLT.- 12 Left Split Liver.- 13 Right Split Liver.- 14 Full-left Full-righr Slit Liver Transplantation.- 15 Outflow liver  obstruction.- 16 Small for Size Syndrome.- 17 Regeneration techniques.- 18 Combined cardiothoracic and abdominal approach.- 19 Portal thrombosis.- 20 Bridging and downstaging: the role of Minimally-invasive surgery.- 21 Robotic surgery in liver transplantation and resection.- 22 Other “bridge” therapies.- 23 General Surgery in Liver transplant recipient.- 24 Anesthesia and resuscitation: from transplantation to major HPB interventions.- 25 Multimodal treatments for liver metastatic NeuroEndocrine Tumors: from resection to transplantation.