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Bucher's chapter, the modem phase ofexperimental studies on liver regeneration started in 1931 with the publication by Higgins and Anderson of a method to perform a two-thirds resection of the liver of a rat.
One Molecular and Cellular Analysis of Liver Growth.- 1 Liver regeneration following partial hepatectomy: genes and metabolism.- 2 Liver regeneration following hepatic injury.- 3 Epithelial stem-like cells of the rodent liver.- 4 Transgenic animals as models for hepatocarcinogenesis.- 5 Gene knockout animal models.- 6 Biological activity of growth factors in vivo.- Two Growth Factors.- 7 The EGF/TGF? family of growth factors and their receptors.- 8 Hepatocyte growth factor in liver growth and differentiation.- 9 The fibroblast growth factor family.- 10 Growth inhibitory signals and liver regeneration: the TGF? superfamily.- 11 Cytokines.- Three Signaling Events.- 12 Proto-oncogenes/transcription factors.- 13 Cyclins and gap junctions in liver growth and repair.- 14 Intracellular signal transduction in liver regeneration.- Four Biology of the Extracellular Matrix and Non-Parenchymal Cells.- 15 Proteoglycans.- 16 Regulation of collagen gene expression.- 17 The extracellular matrix in liver regeneration.- 18 Hepatocyte co-culture, three-dimensional culture models and the extracellular matrix.- 19 Kupffer cells and endothelial cells.- 20 Hepatic stellate cells.- Five Human Liver Growth and Clinical Applications.- 21 Human liver growth and development.- 22 Human liver growth in fibrosis and cirrhosis.- 23 Hepatocyte transplantation: novel applications.- 24 Hepatic gene therapy.- 25 Artificial liver support.