Lipoprotein(a)

Inbunden, Engelska, 2023

Av Karam Kostner, Gerhard M. Kostner, Peter P. Toth

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Data from case control, epigenetic and mendelian randomization studies indicate that people with elevated Lp(a) have a two-fold to four-fold increased risk of cardiovascular events compared to people with low Lp(a) levels.

Produktinformation

Utgivningsdatum2023-03-04
Mått155 x 235 x 29 mm
Vikt942 g
FormatInbunden
SpråkEngelska
SerieContemporary Cardiology
Antal sidor443
FörlagSpringer International Publishing AG
ISBN9783031245749

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Klinisk medicin och internmedicin inom Medicin
Hjärt- och kärlsjukdomar inom Medicin

Karam Kostner, MD, Ph.D., FRACP, FCSANZAssociate Professor of MedicineUniversity of Queensland and Mater HospitalBrisbane, AustraliaGerhard M. Kostner, Ph.D.Emeritus Professor of Biochemistry and Molecular BiologyMedical University of Graz, AustriaGraz, AustriaPeter P. Toth, M.D. , PhD, FAHA, FESC, FACCAdjunct Professor of MedicineDivision of CardiologyJohns Hopkins University School of MedicineBaltimore, Maryland USA

60 years of Lp(a) research-From Ouchterlonys double diffusion to a significant risk factor for CHD.- Lp(a) structure and composition.- Genetics of Lipoprotein(a).- Lp(a) metabolism.- Contemporary aspects of Lp(a) metabolism and therapies based on tracer kinetic methods.- Role of Proprotein Convertase Subtilisin Kexin type 9 in Lipoprotein(a) Metabolism.- The Role of Cell Surface Receptors in Lp(a) Metabolism.- Physiological Roles And Functions Of Lipoprotein(a).- The role of Lp(a) in Atherosclerosis: An overview.- Role of macrophages in Lp(a) pathophysiology.- Thrombosis, Inflammation and Lipoprotein(a): Clinical Implications .- The role of the kidney in Lp(a) physiology and pathophysiology.- Lp(a) as a cardiovascular risk factor.- Lp(a) and aortic valve stenosis, stroke, and other non-coronary cardiovascular diseases.- Lp(a) in cardiovascular disease: Evidence from Large Epidemiological Studies.- Lipoprotein(A) And Immunity.- When to measure Lp(a) .- Measurement of Lipoprotein (a) in the Clinical Laboratory.- Standardization of analytical methods for the measurement of Lipoprotein(a): bridging past and future initiatives.- Establishing an SI-traceable Reference Measurement System for Lp(a), based on Quantitative Protein Mass Spectrometry and Molar Units.- Compounds that impact Lp(a) concentrations.- Antisense oligonucleotide therapy to treat elevated lipoprotein(a).- Lipoprotein apheresis for reduction of Lipoprotein(a).- Elevated Lp(a) - Why Should I Test For It, If I Cannot Treat It? A Patient’s Perspective .- Burning unanswered questions Therapy.