LC-MS in Drug Analysis

• An Introduction to Drug Testing – The Expanding Role of Mass Spectrometry.- LC-MS vs. GC-MS, Online Extraction Systems, Advantages of Technology for Drug Screening Assays.- LC-MS/MS Techniques for High Volume Screening of Drugs of Abuse and Target Drug Quantitation in Urine/Blood Matrices.- Benzodiazepines and Metabolites from Biological Fluids by Liquid Chromatography Electrospray Tandem Mass Spectrometry.- Opiate Screening and Quantitation in Urine/Blood Matrices using LC-MS/MS Techniques.- Synthetic Opioid Analysis by LC-MS/MS.- The Determination of Cannabinoids Using Liquid Chromatography with Mass Spectrometric Detection.- Cocaine and Metabolites by LC-MS/MS.- Quantitation of Amphetamine Type Stimulants by LC-MS/MS.- Detection of Prohibited Substances by Liquid Chromatography Tandem Mass Spectrometry for Sports Doping Control.- LC-MS/MS Screen for Xenobiotics and Metabolites.- Qualitative Identification of Rodenticide Anticoagulants by LC-MS/MS.- Hypoglycemic Agent Screening by LC-MS/MS.- LC-MS/MS Method for the Detection of Common Laxatives.- Simultaneous Determination of Cyclosporine, Sirolimus and Tacrolimus in Whole Blood Using Liquid Chromatography – Tandem Mass Spectrometry (LC-MS/MS).- Quantification of Tricyclic Antidepressants Using UPLC-MS/MS.- Quantitation of First- and Second-Generation Antipsychotics by LC-MS/MS.- Analysis of Selected Anticonvulsants by High Performance Liquid Chromatography-Tandem Mass Spectrometry.- Therapeutic Drug Monitoring of Tamoxifen Using LC-MS/MS..

From the book reviews: "This is a compilation of LC-MS/MS technical procedures for drug analysis. ... It is written for practicing toxicologists or clinical chemists whose daily practice includes analysis for these clinically important substances. It also would be of interest to anyone curious about clinical laboratory testing for any of these compounds or interested in clinical applications of LC-MS/MS. ... You will need this book if you are involved in LC-MS/MS analysis for compounds of clinical interest." (Valerie L. Ng, Doody's Book Reviews, November, 2012)