This publication uses national sources of data on deaths from civil registry offices and health information systems to analyse the impact of the coronavirus disease (COVID-19) on mortality in the countries of the region. In addition, by means of a simulation exercise based on different scenarios of COVID-19 prevalence rates, it estimates the impact of COVID-19-related deaths on life expectancy at birth for the 38 countries and territories of Latin America and the Caribbean. The information used to prepare this edition of the Demographic Observatory corresponds to official information on deaths and causes of death available at 31 October 2020, as well as population estimates and projections prepared by the United Nations.