Del i serien Metal Ions in Life Sciences Series

Lanthanide and Other Transition Metal Ion Complexes and Nanoparticles in Magnetic Resonance Imaging

Inbunden, Engelska, 2024

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Since the development of the first clinical MRI contrast agent, Gd(DTPA) (or Magnevist®) in the early 1980s, another three linear and three macrocyclic (eg. Gd(DOTA) (Dotarem®) have been introduced in the clinic and inspired a huge number of researchers worldwide to perform preclinical research to obtain contrast agents for many kinds of clinical applications, which are described in this book. The most current research has been assembled here and can be used by the scientific community to continue increasing the relevance of metal-containing molecules and nanomaterials for MRI-based diagnosis and thus increase the practical use of these systems.Presents the importance of metal-containing molecules and nanomaterials for MRI-based diagnosis and the practical use of these systems.Discusses the structure and dynamics of Ln-based contrast agents as well as computational studies related to these agents.Endorses and stimulates research in the vibrant field of biological inorganic chemistry.Reviews the most current research supporting the relevance of metal-containing molecules and nanomaterials for diagnosis and therapy.The authors are preeminent bioinorganic and medicinal inorganic chemists and review the most current research in this field.

Produktinformation

Utgivningsdatum2024-08-21
Mått152 x 229 x 27 mm
Vikt453 g
FormatInbunden
SpråkEngelska
SerieMetal Ions in Life Sciences Series
Antal sidor410
FörlagTaylor & Francis Ltd
ISBN9781032438368

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Carlos F. G. C. Geraldes received his “Licenciatura” (MS equivalent) in Chemistry from the University of Coimbra in 1972, and his Doctor of Philosophy (D.Phil) degree in Inorganic Chemistry from the University of Oxford in 1976 with Prof. Robert J. P. Williams. In his graduate work, he studied the solution conformation of a series of mono and dinucleotides using the so-called Lanthanide Probe Method, measuring the proton NMR induced shifts and nuclear relaxation rates of their complexes of whole paramagnetic Ln(III) series combined with coupling constants and NOE data.

Chapter 1 Synthesis and Characterization of Ligands and Their Gd(III) ComplexesRaphaël Tripier, Maryline BeylerChapter 2 PARASHIFT Systems: Including 19F EffectsPeter HarveyChapter 3 Targeted MRI Contrast AgentsAlexander G. Sertage, Md. Sydul Islam, and Matthew J. AllenChapter 4 Responsive MRI Contrast AgentsLuke A. Marchetti, Manon Isaac, Célia S. BonnetChapter 5 Mn-Based Small Complexes as MRI Contrast AgentsZoltán Garda, Sara Lacerda and Éva TóthChapter 6 Other First-Row Transition Metal-Based Complexes as MRI Contrast AgentsJanet R. Morrow and Jaclyn J. Raymond Chapter 7 Lanthanide-based paramagnetic chemical exchange saturation transfer (paraCEST) agents for MRIA. Dean Sherry & Mark WoodsChapter 8 LipoCEST and Similar SystemsSilvio Aime and Enzo TerrenoChapter 9 Superparamagnetic Iron Oxide and Ferrite Nanoparticles for MRIThomas Vangijzegem, Levy Van Leuven, Dimitri Stanicki, Robert N. Muller, Sophie LaurentChapter 10 Ln-based particles as MRI contrast agentsJoop A. Peters and Kristina DjanashviliChapter 11 Manganese and Iron Based Nanoparticles as MRI Contrast AgentsFabio Carniato, Lorenzo Tei, and Carlos F,G. C. GeraldesChapter 12 Advances in PET/MRI and Probe Development for Biomedical Precision Imaging ApplicationsJan Kretschmer, Juan Pellico, Angelina Prytula-Kurkunova, Rafael Torres Martin De Rosales, Andre Ferreira Martins