Landmark Papers in Pain

Dr Paul Farquhar-Smith, MA, MB, BChirFRCA, PhD, FFPMRCA, FFICM, is at present a Consultant in Pain Medicine and Anaesthesia at The Royal Marsden NHS Foundation Trust in London, UK. He specialises in pain in cancer patients and survivors (post-surgical chronic pain, chemotherapy induced neuropathy), and anaesthesia for breast and reconstructive surgery.Dr Pierre Beaulieu is at present a Professor of Anesthesiology and Pharmacology at Université de Montréal in Canada. He specialises in the pharmacology and neurobiology of pain, the use of cannabinoids for treatment of pain, and in local anaestheticsDr Siân Jaggar is at present a Consultant in Anaesthesia at Royal Brompton & Harefield NHS Foundation Trust in London, UK. She specialises in adult and paediatric cardiothoracic anaesthesia and pain relief. She has a particular interest in education as a tool to enhance understanding between different working groups. She is the Royal College deputy regional advisor for the North West Thames region and the lead for less than full time trainees in this region.

• Section 1: Historical 1: JAW (Tony) Wildsmith: Local anaesthetic substitutes for cocaine 2: Ben M. Thomas: Innovative concepts in pain management 3: Sebastian Brandner and Brigitta Brandner: Explaining reflex sympathetic dystrophy 4: Alain Eschalier and Christophe Mallet: The rediscovery of paracetamol 5: Fabrizio Benedetti: The pharmacology of placebos 6: Jean-Sébastien Walczak: Understanding the responsiveness of c-fibres 7: Tony Dickenson: A new theory of pain 8: Manon Choinière and Gabriella Pagé: Three determinants of pain 9: Guy Rousseau: Purinergic nerves: a new type of nerve 10: Jeffrey S. Mogil: Genetic differences in opiate receptors 11: Pierre Rainville: Endogenous opioids in placebo-induced analgesia 12: Éric Troncy: Ethical pain experimentation in conscious animals 13: Argyro Fassoulaki: Local anaesthetic creams 14: Cathy Price: The backpain revolution 15: Pierre Sirois and Pedro D'orléans-Juste: The mechanism of aspirin 16: Yasser Al Omran and Qasim Aziz: Mechanisms of visceral pain in IBS 17: Philippe Richebé and Cyril Rivat: The effects of morphine on the central nervous system 18: Joan Hester: Opiods in palliative care 19: Tony Dickenson: Endogenous opioids in the central nervous system 20: Craig W. Steven: Spinal opioid analgesia in the rat Section 2: Firsts 21: Paul Farquhar-Smith: The key role of NGF in inflammatory pain processing 22: Elizabeth J. Bradbury and Nicholas D. James: Mapping of neurotrophin receptors on adult sensory neurons 23: Stephen R. Humble: Plasticity in somatic receptive fields after nerve injury 24: Amanda Klein and Matthias Ringkamp: Peripheral neural mechanisms of cutaneous hyperalgesia and heat pain 25: Mary E. Abood and Thomas Gamage: The Cloning and Characterization of CB1 26: Mark F. Bird and David Lambert: Deorphanisation of ORL-1/LC132 by reverse pharmacology in two landmark studies 27: Istvan Nagy: The capsaicin receptor 28: Istvan Nagy: Vanilloid receptor 1 in inflammatory thermal hyperalgesia 29: Pierre Rainville: A signature of pain in the brain 30: John Schutzer-Weissmann: Cytokines as central to peripheral sensitisation and hyperalgesia 31: Claudia Sommer: Endogenous opioids mediate stress-induced analgesia 32: Ke Ren Ronald Dubner: The first crystal structure of an iGluR ligand-binding core 33: Andrea Hohmann: Control of pain initiation by endogenous cannabinoids 34: Julie Desroches: Peripheral Analgesia involves Cannabinoid Receptors 35: Marzia Malcangio: Glia: a new pain target 36: Bradley Kerr and Muhammad Saad Yousuf: The challenges of animal models of pain 37: Philippe Sarret: Mechanisms of bone cancer pain 38: Roger Knaggs: Molecular Structure of the Mu-Opioid Receptor 39: Serge Marchand: Milestone Effect of DNIC in our Understanding of Pain 40: Sheila Black: Original description of central sensitisation 41: Lesley Bromley: Molecular basis for Placebo effect Section 3: Science 42: Robert D. Searle: Early discussions on a mechanistic approach to pain 43: Alfredo Ribeiro and Da Silva Claire Magnussen: Plasticity: a key concept in pain 44: Enrique Collantes: The importance of descending modulatory pain systems 45: Helen Laycock: Nocebo and its importance in clinical practice 46: Pierre Beaulieu: Mechanisms of Action of Acetaminophen for Pain Treatment 47: Juergen Sandkuehler: Making the link from central sensitization to clinical pain Section 4: Clinical 48: Vicky Tidman: Proof of concept: epidural morphine 49: Mike Shipley: The Definition of Fibromyalgia 50: Suzanne Chapman: The advent of PCA for post operative analgesia 51: Matthew J. Allsop and Michael Bennett: Undertreatment of pain with metastatic cancer 52: Alison Bliss: Faces scales in paediatric pain assessment 53: Stephan Schug: Epidural block and phantom limb pain 54: Giovambattista Zeppetella: Clarifying the concept of Breakthrough pain Section 5: Mechanisms 55: Alison Bliss: Paediatric pain epidemiology 56: Peter Kamerman: Recognising the importance of HIV disease and pain 57: Andrew N. Davies: Fast acting fentanyl for breakthrough pain 58: Paul Farquhar-Smith: The additive analgesia of adrenaline in epidural blockade 59: Felicia Cox: What is the clinical relevance of the Likert scale for pain 60: Jane Quinlan: Post operative pain: assessing the standards 61: Kirsty Bannister: Opioid induced hyperalgesia 62: Naomi Scott: CRPS epidemiology 63: Paul Farquhar-Smith: Seminal paper on epidemiology of cancer pain 64: Arun Bhaskar: Endoscopic ultrasound guided coeliac plexus block Section 6: Neuropathic 65: Nicholas D. James and Elizabeth J. Bradbury: Autotomy: an early neuropathic pain model 66: Tudor Phillips: Risk factors for post amputation pain 67: Matthew Brown: Chronic constriction injury (CCI) model of neuropathic pain 68: Mick G. Serpell: Antineuropathic medication combination therapy 69: Rajesh Gupta: RCT evidence for gabapentin in post herpetic neuralgia 70: Turo J. Nurmikko: Identification of the target of gabapentinoid action in neuropathic pain 71: Matthew Brown: Recognition of the importance of Neuropathic pain epidemiology 72: Abdelghani Mowafak: Botox analgesia for neuropathic pain 73: Sibtain Anwar: DNIC and prediction of chronic post surgical pain 74: Richard M. Langford: Pregabalin in the reduction of chronic post knee surgery chronic pain 75: Toby Newton John: Multidisciplinary Cognitive Behavioural Treatment for Chronic Pain 76: Rakesh Jain: Disability in Chronic Low Back Pain Section 7: Psychosocial 77: Amanda Williams: The Understanding of Social Effects in Pain Section 8: Genetics 78: Bhagat Singh. Alban Latremoliere, and Michael Costigan: Congenital insensitivity to pain 79: Ingolf Cascorbi: Polymorphic CYP2D6 as the Responsible Enzyme of Activation 80: Matthew Hamilton: COMT genotypes in pain responses 81: Bradley J. Kerr: The link between NaV1.7 mutation and erythromelalgia 82: Fausto Morell-Ducos: COMT and morphine use in cancer pain 83: Roman Cregg and Biloshytsky Vadym: Pioneering use of gene therapy for pain

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