Lahita's Systemic Lupus Erythematosus

Lahita's Systemic Lupus Erythematosus, Seventh Edition is a current, authoritative reference on systemic lupus erythematosus (SLE), one of the most heterogeneous and mechanistically complex of autoimmune diseases. The field has undergone rapid transformation since the previous edition, with regulatory approval of targeted biologics, clarification of molecular mechanisms driving immune dysregulation, and the emergence of precision medicine approaches to patient stratification. This volume addresses the demand for a comprehensive, integrated resource reflecting these advances for specialists in SLE research and clinical care.

The reference spans the full breadth of SLE biology and clinical management. Content covers the genetic and epigenetic determinants of susceptibility, B and T cell dysregulation, innate immune mechanisms including interferon signaling and neutrophil biology, complement activation, microbiome contributions, and metabolic dysfunction in immune cells. Clinical content addresses the presentation and management of SLE across organ systems-including renal, neuropsychiatric, cardiovascular, pulmonary, cutaneous, musculoskeletal, and hematologic manifestations-alongside antiphospholipid syndrome and malignancy surveillance. Therapeutic chapters span antimalarials and glucocorticoids through approved targeted biologics and investigational CAR-T cell approaches, with attention to pregnancy management, global health disparities, and precision treatment strategies.

Lahita's Systemic Lupus Erythematosus equips rheumatologists, clinical immunologists, and multidisciplinary specialists with the scientific foundation and clinical guidance required for contemporary SLE practice. Contributions from international experts spanning five continents provide a global perspective on disease heterogeneity and outcomes. Integrated coverage of AI-assisted monitoring, molecular biomarkers, and precision stratification frameworks positions this reference as essential reading for clinicians and translational researchers in autoimmunity.

. Synthesizes advances in SLE pathogenesis, from genetics and epigenetics to innate and adaptive immunopathogenesis
. Covers approved and investigational therapies including type I interferon blockade and CAR-T cell approaches
. Addresses precision medicine frameworks incorporating AI-driven monitoring and molecular patient stratification
. Provides international perspectives on SLE epidemiology, health disparities, and outcomes