Itch

Advances in itch research have elucidated differences between itch and pain but have also blurred the distinction between them. There is a long debate about how somatic sensations including touch, pain, itch, and temperature sensitivity are encoded by the nervous system. Research suggests that each sensory modality is processed along a fixed, direct-line communication system from the skin to the brain.Itch: Mechanisms and Treatment presents a timely update on all aspects of itch research and the clinical treatment of itch that accompanies many dermatological conditions including psoriasis, neuropathic itch, cutaneous t-cells lymphomas, and systemic diseases such as kidney and liver disease and cancer.Composed of contributions from distinguished researchers around the world, the book explores topics such as:Neuropathic itchPeripheral neuronal mechanism of itchThe role of PAR-2 in neuroimmune communication and itchMrgprs as itch receptorsThe role of interleukin-31 and oncostatin M in itch and neuroimmune communicationSpinal coding of itch and painSpinal microcircuits and the regulation of itchExamining new findings on cellular and molecular mechanisms, the book is a compendium of the most current research on itch, its prevalence in society, and the problems associated with treatment.