Robert R. Wolfe, Ph.D. is currently John H. Sealy Distinguished Chair in Clinical Research at the University of Texas Medical Branch and Chief of Metabolism at the Shriners Burns Hospital in Galveston, Texas. He received his Ph.D. from the University of California, Santa Barbara, spent 8 years as a faculty member at Harvard Medical School, and moved to Galveston in 1983. He is widely recognized for his research in physiological metabolism using isotopically labeled tracers.David L. Chinkes, Ph.D. received his Ph.D. in Mathematical Modeling in Metabolism in 1996 from the University of Texas Medical Branch, and is currently Associate Professor of Surgery and a member of the Metabolism Unit at the Shriners Burns Hospital at Galveston, Texas. His research looks at developing new methods for measuring metabolic parameters in vivo.

• Preface. Chapter 1. Basic Characteristics of Isotopic Tracers.Chapter 2. Calculating Specific Activity and Radiation Dosages.Chapter 3. Calculation of Substance Kinetics: Single-Pool Model.Chapter 4. Calculation of Substrate Kinetics: Multiple-Pool Model.Chapter 5. Mass Spectrometry: Instrumentation.Chapter 6. Determination of Isotopic Enrichment.Chapter 7. Measurement of Substrate Oxidation.Chapter 8. Measurement of Total Energy Expenditure Using the Doubly Labeled Water Method.Chapter 9. Mass Isotopomer Distribution Analysis.Chapter 10. Glucose Metabolism.Chapter 11. Lipid Kinetics.Chapter 12. Whole Body Protein Synthesis and Breakdown.Chapter 13. Measurement of the Synthesis of Specific Proteins.Chapter 14. Measurement of Regional or Tissue Protein Breakdown.Chapter 15. Arterial-Venous Balance Technique to Measure Amino Acid Kinetics.Chapter 16. Nuclear Magnetic Resonance.Glossary.Abbreviations.Index.

"...is supported by a wealth of illustrations, tables, and exemplary calculations that will aid in comprehension...[an] excellent and much needed textbook." (The Quarterly Review of Biology, March 2007) "...should be required for anyone who desires to know more about metabolic tracer kinetics." (Journal of the American Society for Mass Spectrometry, September 2005)"...an effective integration of theory and practical implementation...It effectively serves as a teaching textbook as well as a research item." (E-STREAMS, August 2005)

Robert R. Wolfe, Ph.D. is currently John H. Sealy Distinguished Chair in Clinical Research at the University of Texas Medical Branch and Chief of Metabolism at the Shriners Burns Hospital in Galveston, Texas. He received his Ph.D. from the University of California, Santa Barbara, spent 8 years as a faculty member at Harvard Medical School, and moved to Galveston in 1983. He is widely recognized for his research in physiological metabolism using isotopically labeled tracers.David L. Chinkes, Ph.D. received his Ph.D. in Mathematical Modeling in Metabolism in 1996 from the University of Texas Medical Branch, and is currently Associate Professor of Surgery and a member of the Metabolism Unit at the Shriners Burns Hospital at Galveston, Texas. His research looks at developing new methods for measuring metabolic parameters in vivo.

• Preface. Chapter 1. Basic Characteristics of Isotopic Tracers.Chapter 2. Calculating Specific Activity and Radiation Dosages.Chapter 3. Calculation of Substance Kinetics: Single-Pool Model.Chapter 4. Calculation of Substrate Kinetics: Multiple-Pool Model.Chapter 5. Mass Spectrometry: Instrumentation.Chapter 6. Determination of Isotopic Enrichment.Chapter 7. Measurement of Substrate Oxidation.Chapter 8. Measurement of Total Energy Expenditure Using the Doubly Labeled Water Method.Chapter 9. Mass Isotopomer Distribution Analysis.Chapter 10. Glucose Metabolism.Chapter 11. Lipid Kinetics.Chapter 12. Whole Body Protein Synthesis and Breakdown.Chapter 13. Measurement of the Synthesis of Specific Proteins.Chapter 14. Measurement of Regional or Tissue Protein Breakdown.Chapter 15. Arterial-Venous Balance Technique to Measure Amino Acid Kinetics.Chapter 16. Nuclear Magnetic Resonance.Glossary.Abbreviations.Index.

"...is supported by a wealth of illustrations, tables, and exemplary calculations that will aid in comprehension...[an] excellent and much needed textbook." (The Quarterly Review of Biology, March 2007) "...should be required for anyone who desires to know more about metabolic tracer kinetics." (Journal of the American Society for Mass Spectrometry, September 2005)"...an effective integration of theory and practical implementation...It effectively serves as a teaching textbook as well as a research item." (E-STREAMS, August 2005)

Robert R. Wolfe, Ph.D. is currently John H. Sealy Distinguished Chair in Clinical Research at the University of Texas Medical Branch and Chief of Metabolism at the Shriners Burns Hospital in Galveston, Texas. He received his Ph.D. from the University of California, Santa Barbara, spent 8 years as a faculty member at Harvard Medical School, and moved to Galveston in 1983. He is widely recognized for his research in physiological metabolism using isotopically labeled tracers.David L. Chinkes, Ph.D. received his Ph.D. in Mathematical Modeling in Metabolism in 1996 from the University of Texas Medical Branch, and is currently Associate Professor of Surgery and a member of the Metabolism Unit at the Shriners Burns Hospital at Galveston, Texas. His research looks at developing new methods for measuring metabolic parameters in vivo.

• Preface. Chapter 1. Basic Characteristics of Isotopic Tracers.Chapter 2. Calculating Specific Activity and Radiation Dosages.Chapter 3. Calculation of Substance Kinetics: Single-Pool Model.Chapter 4. Calculation of Substrate Kinetics: Multiple-Pool Model.Chapter 5. Mass Spectrometry: Instrumentation.Chapter 6. Determination of Isotopic Enrichment.Chapter 7. Measurement of Substrate Oxidation.Chapter 8. Measurement of Total Energy Expenditure Using the Doubly Labeled Water Method.Chapter 9. Mass Isotopomer Distribution Analysis.Chapter 10. Glucose Metabolism.Chapter 11. Lipid Kinetics.Chapter 12. Whole Body Protein Synthesis and Breakdown.Chapter 13. Measurement of the Synthesis of Specific Proteins.Chapter 14. Measurement of Regional or Tissue Protein Breakdown.Chapter 15. Arterial-Venous Balance Technique to Measure Amino Acid Kinetics.Chapter 16. Nuclear Magnetic Resonance.Glossary.Abbreviations.Index.

"...is supported by a wealth of illustrations, tables, and exemplary calculations that will aid in comprehension...[an] excellent and much needed textbook." (The Quarterly Review of Biology, March 2007) "...should be required for anyone who desires to know more about metabolic tracer kinetics." (Journal of the American Society for Mass Spectrometry, September 2005)"...an effective integration of theory and practical implementation...It effectively serves as a teaching textbook as well as a research item." (E-STREAMS, August 2005)