Isoprenoid Synthesis in Plants and Microorganisms

Thomas J. BachDépartement Réseaux métaboliques, Institut de Biologie Moléculaire des Plantes, University of Strasbourg, Strasbourg, FranceMichel RohmerInstitut Le Bel, Université Louis Pasteur, Strasbourg, France

• Isoprenoid Bbiosynthesis in Pprokaryotic Organisms.- 1-deoxy-D-xylulose 5-phosphate Synthase (DXS), A Crucial Enzyme for Isoprenoids Biosynthesis.- Biosynthetic Genes and Enzymes of Isoprenoids Produced by Actinomycetes.- Interactions of Isoprenoid Pathway Enzymes and Indirect Stimulation of Isoprenoid Biosynthesis by Pentose Phosphate Cycle Substrates in Synechocystis PCC 6803.- Metabolic Engineering of Monoterpenoids Production in Yeast.- Metabolic Engineering of Isoprenoid Production: Reconstruction of Multistep Heterologous Pathways in Tractable Hosts.- Microbially-Derived Semi-synthetic Artemisinin.- Artemisinin: Controlling its Production in Artemisia Annua.- Fosmidomycin as an Antimalarial Agent.- Regulation of Isoprene and Monoterpene Emission.- Involvement of Compartmentalization in Monoterpene and Sesquiterpene Biosynthesis in Plants.- Strategies for the Manipulation of Carbocations by Aristolochene Synthase.- Elucidating the Formation of Geranyllinalool, the Precursor of the Volatile C16-homoterpene TMTT Involved in Indirect Plant Defense.- Strigolactones: A Cry for Help Results in Fatal Attraction. Is Escape Possible?.- Prenyldiphosphate Synthases and Gibberellin Biosynthesis.- Gibberellin Phytohormone Metabolism.- Control of Plastidial Isoprenoid Precursor Supply: Divergent 1-deoxy-D-xylulose 5-phosphate Synthase (DXS) Isogenes Regulate the Allocation to Primary or Secondary Metabolism.- Tobacco Trichomes as a Platform for Terpenoid Biosynthesis Engineering.- Prenylated Proteins are Required for Methyl jasmonate-induced Monoterpenoid Indole Alkaloids Biosynthesis in Catharanthus roseus.- The Role of Prenylcysteine Methylation and Metabolism in Abscisic Acid Signaling in Arabidopsis Thaliana.- What We Do and Do Not Know About the Cellular Functions of Polyisoprenoids.- Regulation of 3-hydroxy-3-methylglutaryl-CoA Synthase and 3-hydroxy-3-methylglutaryl-CoA Reductase and Rubber Biosynthesis of Hevea brasiliensis (B.H.K.) Mull. Arg.- Development of Crops to Produce Industrially Useful Natural Rubber.- Occurrence in Tobacco of Two Acetoacetyl-Coenzyme A Thiolases with Distinct Expression Patterns and Subcellular Localization.- The Sterol C4-Demethylation in Higher Plants.- Sterol C22-desaturase and its Biological Roles.- Enzymatic Synthesis of Unnatural Cyclic Triterpenes.- Saponin Synthesis and Function.- Cardenolide Aglycone Formation in Digitalis.- Biosynthesis of Isoprenoid Precursors in Arabidopsis.- Understanding the Mechanisms that Modulate the MEP Pathway in Higher Plants.- Functional Analysis of HMG-CoA Reductase and Oxidosqualene Cyclases in Arabidopsis.- Systems Understanding of Isoprenoid Pathway Regulation in Arabidopsis.