Irritable Bowel Syndrome

Takeshi Kamiya, Nagoya City University, JapanShin Fukudo, Tohoku University, Japan

• Definition of irritable bowel syndrome.- The epidemiology of irritable bowel syndrome.- Part II. Pathophysiology.- Neurogastroenterology - Brain-Gut Axis, Stress and Psychological Factors.- Neuro-gastroenterology - Neurotransmitter, endocrine substance and motility.- Role of microbiota in the pathophysiology of irritable bowel syndrome.- Mucosal inflammation and visceral hypersensitivity in irritable bowel syndrome.- Genetic factors.- Part III. Diagnosis.- Diagnostic algorithm for IBS.- Differential diagnosis.- Comorbiditie.- Part IV. Treatment.- Pharmacotherapy for IBS-D.- Pharmacotherapy for irritable bowel syndrome with constipation.- GI motility modifier, bulking polymer and Herbal medicine.- Antidepressant, anxiolytics and psychotherapy.- Diet and behavioral modification for irritable bowel syndrome.- Probiotics and antibiotics.- Part V. Recent special topics.- Fecal Microbiota Transplantation for Treatment of Irritable Bowel Syndrome.- Clinical study design and evaluation of the efficacy in the treatment.