Ion Channels as Therapeutic Targets, Part B

Rossen Donev received his PhD degree in 1999 from the Institute of Molecular Biology, Bulgarian Academy of Sciences. He did postdoctoral training at Imperial Cancer Research Fund, UK (renamed after the merger with Cancer Research Campaign to Cancer Research UK, London Research Institute) and Cardiff University. In 2007 he was awarded a New Investigator Grant Award from the Medical Research Council (UK) to establish himself as an independent Principle Investigator. In 2010 Dr. Donev was appointed Senior Lecturer at Swansea University. In 2016 Dr. Donev joined MicroPharm Ltd (UK) where currently he is Head of Research. He has published more than 60 research papers, chaired scientific meetings and given invited plenary talks. Rossen Donev has consulted on projects related to development of treatments for neurodevelopmental disorders and cancer therapies. He serves as Editor-in-Chief of the Advances in Protein Chemistry and Structural Biology and on editorial board of several other journals. His research interests include signaling pathways involved in neuropsychiatric disorders and tumor escape from the immune system, and development of therapeutic strategies for their treatment. More recently he has focused on development of immunotherapeutics for non-systemic applications.

• 1. Role of Hemichannels in CNS Inflammation and the Inflammasome PathwayYuri Kim, Joanne O. Davidson, Katherine C. Gunn, Anthony R. Phillips, Colin R. Green and Alistair J. Gunn2. P2X7 Receptors as a Therapeutic TargetElena De Marchi, Elisa Orioli, Diego Dal Ben and Elena Adinolfi3. Polymodal Transient Receptor Potential Vanilloid Type 1 (TRPV1) Nocisensor: Structure, Modulators, and Therapeutic ApplicationsMinghua Cui, Vijayakumar Gosu, Shaherin Basith, Sunhye Hong and Sun Choi4. TRPM8 ion Channels as Potential Cancer Biomarker and Target in Pancreatic CancerNelson S. Yee5. Ion Channels In The Eye: Involvement In Ocular PathologiesJonathan P Giblin, Nuria Comes, Olaf Strauss and Xavier Gasull6. Calcium-Activated Potassium Channels: Potential Target for Cardiovascular DiseasesDe-Li Dong, Yun-Long Bai and Ben-Zhi Cai 7. The Modulation of Potassium Channels in the Smooth Muscle as a Therapeutic Strategy for Disorders of the Gastrointestinal TractDiego Currò8. Targeting the Channel Activity of ViroporinsJanet To, Wahyu Surya and Jaume Torres9. Contribution of Automated Technologies to Ion Channel Drug DiscoveryArturo Picones, Arlet Loza-Huerta, Pedro Segura-Chama and Cesar O. Lara Figueroa