The guest editors for this issue, Talmadge King, Harold Collard, celebrated pulmonary specialists from UCSF, and Luca Richeldi, renowned visiting professor to UCSF from University of Modena, Italy, bring together a state-of-the-art issue on the important topic of Interstitial Lung Diseases (ILD).� This comprehensive issue reviews the approach to diagnosis of ILD, radiology if ILD, pathology of ILD.� Idiopathic pulmonary fibrosis is discussed, including phenotypes and comorbidities, acute exacerbation and accelerated decline, management, and pathobiology of novel approaches to therapy.� Connective Tissue ILD, Chronic Hypersensitivity Pneumonitis, familial ILD and smoking-related ILD, and non-specific interstitial pneumonia are reviewed.� In the final article, lung transplantation is discussed.