Intermittent and Periodic Fasting, Aging and Disease

Krista Varady, PhD, is a Professor of Nutrition at the University of Illinois, Chicago. Her research focuses on the efficacy of intermittent fasting for weight management and metabolic disease risk reduction in adults with obesity. She has been studying fasting for almost 20 years and is one of the top researchers in this field. Her work is funded by the NIH, American Heart Association, and the University of Illinois. She has published over 100 publications on this topic and is also the author of two books for the general public, entitled the "Every Other Day Diet" and “The Fastest Diet”.Emily Manoogian, PhD is a staff scientist and the head of clinical research in Dr. Satchin Panda’s lab at the Salk Institute for Biological Studies. She has studied circadian rhythms for the past 15 years at the mechanistic and clinical levels. Currently, her research focuses on how lifestyle interventions that optimize circadian health, such as time-restricted eating, can improve a variety of age-related diseases including pre-diabetes, diabetes, cardiovascular disease,  cancer, mental health, and cognitive decline.Valter Longo, PhD, is the Edna Jones Professor in Gerontology, the Director of the USC Longevity Institute and group leader at the IFOM cancer research institute in Milan, Italy. His laboratories study the fundamental mechanisms of aging in yeast, rodents and humans by using genetics and biochemistry techniques. The focus is on the nutrient-response signal transduction pathways that regulate disease and longevity. This work led to the discovery of the effects of periodic fasting and fasting mimicking diets on multi-system stem cell activation and regeneration in mice, and to clinical trials on a range of age-related diseases.

• Part I: Calorie Restriction.- Chapter 1: Caloric Restriction and Biomarkers of Aging.- Part II: Protein Restriction.- Chapter 2: Protein Restriction in aging and Disease.- Part III: Intermittent Fasting - Time Restricted Eating.- Chapter 3: Time-Restricted Feeding for the prevention and management of metabolic diseases in animal models and humans.- Chapter 4: Time Restricted Eating: Effects on Body Weight and Metabolic Disease Risk Factors.- Chapter 5: Time Restricted Eating: Safety and efficacy in youth.- Part IV: Intermittent Fasting - Alternate Day Fasting and 5:2.- Chapter 6: Alternate Day Fasting and the 5:2 Diet: Effects on Body Weight and Metabolic Disease Risk Factors.- Chapter 7: Cellular Adaptations to Intermittent Fasting: Impact on Brain.- Part V: Periodic Fasting.- Chapter 8: Periodic Fasting: Evolutionary Perspectives Explaining the Clinical Benefits.- Chapter 9: Fasting Mimicking Diets in Longevity and Disease.- Chapter 10: Effectiveness of Periodic Fasting intreating Human Chronic Diseases: Clinical Evidence and Empirical Insights from a Specialized University Medical Center.