A great deal of new information has been obtained during thepast four years, and this monograph provides a clear andwell reviewed update on biochemical mechanisms and theresults of important new clinical studies using theinterferons.Reviews include what is presently known about thebiosynthesis, physiological role and mechanisms of action ofthe interferons (alpha, beta, gamma). New biochemicalinformation on interferon-receptor interactions andsignalling pathways is provided. The pharmacokineticconsiderations in treating leukemia, lymphoma, myeloma,neuroendocrine tumors and other solid tumors are reviewedwith special emphasis on studies of adjuvant chemotherapy inmalignancies of the immune system.