This book contains the reviewed, accepted contributions ofthe First International Symposium on Intelligent Computing Systems (ISICS) that was held in Merida (Mexico) from 16-18 March 2016.  We received 25 submissions from 13 countries. Eachsubmission had been evaluated by at least three members of the ProgramCommittee and external reviewers. Based on these reviews, 12 papers wereselected for long oral presentation. In addition to the contributed papers,four keynote speaker presentations were included in the conference program.