This book constitutes the refereed post-conference proceedings of the 4th International Conference on Intelligence Science, ICIS 2020, held in Durgapur, India, in February 2021 (originally November 2020).The 23 full papers and 4 short papers presented were carefully reviewed and selected from 42 submissions. One extended abstract is also included. They deal with key issues in brain cognition; uncertain theory; machine learning; data intelligence; language cognition; vision cognition; perceptual intelligence; intelligent robot; and medical artificial intelligence.